Advances in developing therapeutic strategies for Alzheimer's disease

被引:70
作者
Nguyen, Thuy Trang [1 ]
Nguyen, Thi Thuy Dung [2 ]
Nguyen, Thi Kim Oanh [3 ]
Vo, Tuong Kha [4 ]
Vo, Van Giau [5 ,6 ]
机构
[1] Ho Chi Minh City Univ Technol HUTECH, Fac Pharm, Ho Chi Minh City 700000, Vietnam
[2] Nguyen Tat Thanh Univ, Fac Environm & Food Engn, Ho Chi Minh City 700000, Vietnam
[3] Ho Chi Minh City Univ Food Ind, Fac Food Sci & Technol, Ho Chi Minh City 700000, Vietnam
[4] Vietnam Sports Hosp, Minist Culture Sports & Tourism, Hanoi 100000, Vietnam
[5] Ton Duc Thang Univ, Bionanotechnol Res Grp, Ho Chi Minh City 700000, Vietnam
[6] Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City 700000, Vietnam
关键词
Alzheimer's disease; Nanocarriers; A beta; Tau; CNS; BLOOD-BRAIN-BARRIER; TANSHINONE IIA NANOPARTICLES; IRON-OXIDE NANOPARTICLES; GRAPHENE QUANTUM DOTS; A-BETA; AMYLOID-BETA; OXIDATIVE STRESS; FIBRIL GROWTH; DELIVERY; PEPTIDE;
D O I
10.1016/j.biopha.2021.111623
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Alzheimer's disease (AD) is a progressive deterioration of brain function, initially characterized by cognitive deficits, with loss of recent memory and language ability, impairment of orientation, problem solving, and abstract thinking. While existing drug treatments help reduce the symptoms of AD and improve people's quality of life, they neither slow its progression nor cure it. Currently, targeted drug delivery to the central nervous system (CNS), for therapy of AD, is confined by the challenges posed by blood-brain interfaces surrounding the CNS, limiting the bioavailability of therapeutics. Among new strategies to overcome these limitations and successfully deliver drugs to the CNS, nanoparticles (NPs) are able to overcome these limitations, offering new therapeutic designations in term of driving drugs to cross the BBB and enter the brain more effectively. The current article aimed to summary and highlight advances in recent research on the development of nanotechnology-based therapeutics for their implications in therapy of AD.
引用
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页数:10
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