The purpose of the study was to assess whether alignment of the entire hindfoot in connection with total ankle replacement in rheumatoid arthritis (RA) was a lasting treatment. During the period 1981 - 2003 fifty-six cases of RA were treated with total ankle replacement. There were 45 patients (11 bilateral cases), 37 women and 8 men. The patients mean age at the operation was 57 years (range 30 - 83). Preoperatively loading of the hindfoot showed valgus (>7degrees) in 41 cases, and varus (>3degrees) in 6 cases. Nine cases were within normal hindfoot alignment. The preoperative Kofoed score was mean 24.5 points (range 6-44). All patients attended follow-ups with radiographs taken under image intensification. The scoring at the latest follow-up of surviving prostheses was median 84 (range 34 - 98). Six cases were re-operated upon. Two were revised and 4 were changed into arthrodesis. The consistency of alignment was noticed and compared to the clinical end result. Preoperatively, valgus of the hindfoot was mean 15.5degrees +/- 8.1 S.E. in 41 cases. At the latest follow-up the hindfoot valgus was mean 4.9degrees +/- 6.6 S.E., p < 0.0001. Preopartively, six cases showed hindfoot varus of mean 13.3degrees +/- 7.9 S.E. At the latest follow-up the hindfoot varus was mean 1.3degrees +/- 3.5 S.E., p < 0.0001. Forty-four of the 50 cases with the original prosthesis in situ showed normal alignment at the latest follow-up. Cases with normal hindfoot alignment scored mean 86 points (69-98). Cases with abnormal hindfoot alignment scored mean 77 points (34-90), p < 0.02. From this study with long-term follow-up it was concluded that entire hindfoot alignment is mandatory.