Glycolipids from sponges .4. Immunomodulating glycosyl ceramides from the marine sponge Agelas dispar.

被引：55
作者：
Costantino, V
Fattorusso, E
Mangoni, A
DiRosa, M
Ianaro, A
Maffia, P
机构：
[1] DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY
[2] DIPARTIMENTO FARMACOL SPERIMENTALE,I-80131 NAPLES,ITALY
来源：
TETRAHEDRON | 1996年 / 52卷 / 05期
关键词：
D O I：
10.1016/0040-4020(95)00986-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The GSL composition of the marine sponge Agelas dispar was investigated. In addition to four GSLs previously isolated from Agelas clathrodes (2 and 4), Agelas conifera (3), and Agelas longissima (5), the novel triglycosylceramide 1a was isolated as a major component of the GSL mixture. All the isolated GSLs were tested using the MLR assay, and only some of them were shown to be immunoactivating agents, suggesting a possible structure-activity relationship.
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页码：1573 / 1578
页数：6
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