Next Generation Sequencing Data and Proteogenomics

被引：4
|
作者：
Ruggles, Kelly V. [1 ,2 ]
Fenyo, David [3 ,4 ]
机构：
[1] NYU, Med Ctr, Dept Med, 550 First Ave, New York, NY 10016 USA
[2] NYU, Med Ctr, Ctr Hlth Informat & Bioinformat, 227 East 30th St, New York, NY 10016 USA
[3] NYU, Med Ctr, Inst Syst Genet, 430 East 29th St, New York, NY 10016 USA
[4] NYU, Med Ctr, Dept Biochem & Mol Pharmacol, 550 First Ave, New York, NY 10016 USA
来源：
PROTEOGENOMICS | 2016年 / 926卷
关键词：
Next generation sequencing; Proteogenomic integration; Bioinformatics; Peptide identification; Gene annotation; RNA-SEQ DATA; MASS-SPECTROMETRY; GENOME ANNOTATION; READ ALIGNMENT; GENE; IDENTIFICATION; INSERTIONS; DATABASES; DELETIONS; PACKAGE;
D O I：
10.1007/978-3-319-42316-6_2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The field of proteogenomics has been driven by combined advances in next-generation sequencing (NGS) and proteomic methods. NGS technologies are now both rapid and affordable, making it feasible to include sequencing in the clinic and academic research setting. Alongside the improvements in sequencing technologies, methods in high throughput proteomics have increased the depth of coverage and the speed of analysis. The integration of these data types using continuously evolving bioinformatics methods allows for improvements in gene and protein annotation, and a more comprehensive understanding of biological systems.
引用
收藏
页码：11 / 19
页数：9
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