Estrogen receptor α expression in mice kidney shows sex differences during aging

被引：31

作者：

Sharma, PK ^{[1
]}

Thakur, MK ^{[1
]}

机构：

[1] Banaras Hindu Univ, Ctr Adv Study Zool, Biochem & Mol Biol Lab, Varanasi 221005, Uttar Pradesh, India

来源：

BIOGERONTOLOGY | 2004年 / 5卷 / 06期

关键词：

aging; estrogen receptor; kidney; mice; semi quantitative RT-PCR; western blot;

D O I：

10.1007/s10522-004-3191-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We have used semi quantitative RT-PCR and western blotting for the analysis of expression of estrogen receptor (ER) alpha and beta mRNA and protein in the kidney of adult and old mice of both sexes. Uterus, a well-known target for estrogen action, was used for comparison. As compared to adult, the expression of both ER alpha mRNA and protein of old mice decreased in male but increased in female. However, unlike uterus, neither ERbeta mRNA nor protein could be detected in the kidney of adult or old mice. Thus the present data reveal that the expression of ERalpha in mice kidney shows sex differences during aging.

引用

页码：375 / 381

页数：7

共 38 条

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