Transmission of BSE by blood transfusion in sheep

被引：433

作者：

Houston, F

Foster, JD

Chong, A

Hunter, N ^{[1
]}

Bostock, CJ

机构：

[1] Inst Anim Hlth, Neuropathogenesis Unit, Edinburgh EH9 3JF, Midlothian, Scotland

[2] AFRC, Inst Anim Hlth, Newbury RG16 0NN, Berks, England

来源：

LANCET | 2000年 / 356卷 / 9234期

关键词：

D O I：

10.1016/S0140-6736(00)02719-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have shown that it is possible to transmit bovine spongiform encephalopathy (BSE) to a sheep by transfusion with whole blood taken from another sheep during the symptom-free phase of an experimental BSE infection. BSE and variant Creutzfeldt-Jakob disease (vCJD) in human beings are caused by the same infectious agent, and the sheep-BSE experimental model has a similar pathogenesis to that of human vCJD. Although Uh blood transfusions ale leucodepleted-a possible protective measure against any risk from blood transmission-this report suggests that blood donated by symptom-free vCJD-infected human beings may represent a risk of spread of vCJD infection among the human population of the UK.

引用

页码：999 / 1000

页数：2

共 5 条

[1]

BRUCE ME, 1997, NATURE, V389, P488

[2] Detection of BSE infectivity in brain and spleen of experimentally infected sheep [J].