The internal structure of mitochondria

被引:631
作者
Frey, TG [1 ]
Mannella, CA
机构
[1] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA
[2] Wadsworth Ctr, Albany, NY 12201 USA
关键词
D O I
10.1016/S0968-0004(00)01609-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Electron microscopic (EM) tomography is providing important new insights into the internal organization of mitochondria. The standard baffle model for cristae structure, called into question years ago, has now clearly been shown to be inaccurate. Depending on source and conformational state, cristae can vary from simple tubular structures to more complex lamellar structures merging with the inner boundary membrane through tubular structures 28 nm in diameter. The structural information provided by EM tomography has important implications for mitochondrial bioenergetics, biogenesis and the role of mitochondria in apoptosis. The structural paradigm defined by EM tomography is helping in the design of new experimental approaches to mitochondrial function.
引用
收藏
页码:319 / 324
页数:6
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