Advances in Cell Scaffolds for Tissue Engineering: The Value of Liquid Crystalline Elastomers

被引：52

作者：

Martella, Daniele ^{[1
,2
,3
]}

Parmeggiani, Camilla ^{[1
,2
,3
]}

机构：

[1] Univ Florence, Chem Dept Ugo Schiff, Via Lastruccia 3-13, Sesto Fiorentino, Italy

[2] Univ Florence, CNR INO, Via Nello Carrara 1, Sesto Fiorentino, Italy

[3] Univ Florence, European Lab Nonlinear Spect LENS, Via Nello Carrara 1, Sesto Fiorentino, Italy

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2018年 / 24卷 / 47期

基金：

欧洲研究理事会;

关键词：

biomaterials; cell alignment; cell scaffolds; liquid crystal elastomers; tissue engineering; PHOTOMOBILE POLYMER MATERIALS; MAIN-CHAIN POLYMERS; TOPOLOGICAL DEFECTS; SOFT LITHOGRAPHY; ACTUATORS; ALIGNMENT; NETWORKS; CULTURE; SHAPE; MICROSTRUCTURES;

D O I：

10.1002/chem.201800477

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent discoveries evidenced that many cells organize into well-aligned nematic domains, showing also their topological defects and suggesting the liquid crystalline order to be necessary for some biological functions. These evidences were described as the basis for the development of a new area of research in which polymeric liquid crystals were developed to exploit and promote cell adhesion and proliferation towards tissue regeneration. To address the requirements of tissue engineering, new biocompatible materials must be designed and synthesized to support cell adherence and growth together with nutrient transport under physiological condition. This Minireview presents a journey that, starting from the first discovery of liquid crystalline phases in biological (natural) materials with different structures and physical-chemical properties, will inform readers of the very recent application of liquid crystal polymeric materials as functional cell scaffolds to address current tissue engineering issues.

引用

页码：12206 / 12220

页数：15

共 82 条

[1] Optically Responsive and Mechanically Tunable Colloid-In-Liquid Crystal Gels that Support Growth of Fibroblasts [J].