Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection

被引：15

作者：

Rajala, Ammaji ^{[1
,2
]}

Teel, Kenneth ^{[1
,2
]}

Bhat, Mohd A. ^{[1
,2
]}

Batushansky, Albert ^{[3
]}

Griffin, Timothy M. ^{[3
]}

Purcell, Lindsey ^{[1
,2
]}

Rajala, Raju V. S. ^{[1
,2
,4
,5
]}

机构：

[1] Univ Oklahoma, Dept Ophthalmol, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

[2] Dean McGee Eye Inst, Oklahoma City, OK 73104 USA

[3] Oklahoma Med Res Fdn, Oklahoma City, OK 73014 USA

[4] Univ Oklahoma, Dept Physiol, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

[5] Univ Oklahoma, Dept Cell Biol, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

来源：

CELL DEATH & DISEASE | 2022年 / 13卷 / 07期

基金：

美国国家卫生研究院;

关键词：

PRECONDITIONING-INDUCED PROTECTION; LEUKEMIA INHIBITORY FACTOR; FACTOR-I IGF-1; GLUCOSE-INTOLERANCE; SURVIVAL SIGNAL; MICE LACKING; CELLS; ACTIVATION; DELETION; RETINA;

D O I：

10.1038/s41419-022-05074-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and microcephaly. IGF-1R is expressed in the retina and photoreceptor neurons; however, its functional role is not known. Global IGF-1 KO mice have age-related vision loss. We determined that conditional deletion of IGF-1R in photoreceptors and pan-retinal cells produces age-related visual function loss and retinal degeneration. Retinal pigment epithelial cell-secreted IGF-1 may be a source for IGF-1R activation in the retina. Altered retinal, fatty acid, and phosphoinositide metabolism are observed in photoreceptor and retinal cells lacking IGF-1R. Our results suggest that the IGF-1R pathway is indispensable for photoreceptor survival, and activation of IGF-1R may be an essential element of photoreceptor and retinal neuroprotection.

引用

页数：14

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