Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL

被引:19
作者
Bond, Jonathan [1 ]
Bergon, Aurelie [2 ,3 ]
Durand, Amandine [1 ]
Tigaud, Isabelle [4 ]
Thomas, Xavier [5 ]
Asnafi, Vahid [1 ]
Spicuglia, Salvatore [3 ]
Macintyre, Elizabeth [6 ]
机构
[1] Univ Sorbonne Paris Cite, Fac Med Descartes, INSERM U1151, Hop Necker Enfants Malad,AP HP,Lab Oncohematol, Paris, France
[2] Transcript & Genom Marseille Luminy, Infrastruct Biol Sante & Agron Platform, Marseille, France
[3] Aix Marseille Univ, UMR S 1090, INSERM U1090, Marseille, France
[4] Ctr Hosp Lyon Sud, Cytogenet & Mol Biol Lab, F-69310 Pierre Benite, France
[5] Hop Edouard Herriot, Dept Hematol, Lyon, France
[6] Univ Sorbonne Paris Cite, Fac Med Descartes, Inst Necker Enfants Malades,INSERM U1151, Hop Necker Enfants Malad,AP HP,Lab Oncohematol, Paris, France
关键词
ACUTE LYMPHOBLASTIC-LEUKEMIA; FUSION; INHIBITION; LINEAGE; KPT-330; TCR;
D O I
10.1182/blood-2014-04-567636
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:3023 / 3025
页数:5
相关论文
共 10 条
[1]   CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCR-γδ lineage [J].
Asnafi, V ;
Radford-Weiss, I ;
Dastugue, N ;
Bayle, C ;
Leboeuf, D ;
Charrin, C ;
Garand, R ;
Lafage-Pochitaloff, M ;
Delabesse, E ;
Buzyn, A ;
Troussard, X ;
Macintyre, E .
BLOOD, 2003, 102 (03) :1000-1006
[2]   Analysis of TCR, pTα, and RAG-1 in T-acute lymphoblastic leukemias improves understanding of early human T-lymphoid lineage commitment [J].
Asnafi, V ;
Beldjord, K ;
Boulanger, E ;
Comba, B ;
Le Tutour, P ;
Estienne, MH ;
Davi, F ;
Landman-Parker, J ;
Quartier, P ;
Buzyn, A ;
Delabesse, E ;
Valensi, F ;
Macintyre, E .
BLOOD, 2003, 101 (07) :2693-2703
[3]   The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest [J].
Ben Abdelali, Raouf ;
Asnafi, Vahid ;
Petit, Arnaud ;
Micol, Jean-Baptiste ;
Callens, Celine ;
Villarese, Patrick ;
Delabesse, Eric ;
Reman, Oumedaly ;
Lepretre, Stephane ;
Cahn, Jean-Yves ;
Guillerm, Gaelle ;
Berthon, Celine ;
Gardin, Claude ;
Corront, Bernadette ;
Leguay, Thibaut ;
Bene, Marie-Christine ;
Ifrah, Norbert ;
Leverger, Guy ;
Dombret, Herve ;
Macintyre, Elizabeth .
HAEMATOLOGICA, 2013, 98 (11) :1711-1717
[4]   New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia [J].
Brandimarte, Lucia ;
Pierini, Valentina ;
Di Giacomo, Danika ;
Borga, Chiara ;
Nozza, Filomena ;
Gorello, Paolo ;
Giordan, Marco ;
Cazzaniga, Giovanni ;
te Kronnie, Geertruy ;
La Starza, Roberta ;
Mecucci, Cristina .
BLOOD, 2013, 121 (25) :5064-5067
[5]   Potent inhibition of DOT1L as treatment of MLL-fusion leukemia [J].
Daigle, Scott R. ;
Olhava, Edward J. ;
Therkelsen, Carly A. ;
Basavapathruni, Aravind ;
Jin, Lei ;
Boriack-Sjodin, P. Ann ;
Allain, Christina J. ;
Klaus, Christine R. ;
Raimondi, Alejandra ;
Scott, Margaret Porter ;
Waters, Nigel J. ;
Chesworth, Richard ;
Moyer, Mikel P. ;
Copeland, Robert A. ;
Richon, Victoria M. ;
Pollock, Roy M. .
BLOOD, 2013, 122 (06) :1017-1025
[6]   KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia [J].
Etchin, Julia ;
Sanda, Takaomi ;
Mansour, Marc R. ;
Kentsis, Alex ;
Montero, Joan ;
Le, Bonnie T. ;
Christie, Amanda L. ;
McCauley, Dilara ;
Rodig, Scott J. ;
Kauffman, Michael ;
Shacham, Sharon ;
Stone, Richard ;
Letai, Anthony ;
Kung, Andrew L. ;
Look, A. Thomas .
BRITISH JOURNAL OF HAEMATOLOGY, 2013, 161 (01) :117-127
[7]   The MLL recombinome of acute leukemias in 2013 [J].
Meyer, C. ;
Hofmann, J. ;
Burmeister, T. ;
Groeger, D. ;
Park, T. S. ;
Emerenciano, M. ;
de Oliveira, M. Pombo ;
Renneville, A. ;
Villarese, P. ;
Macintyre, E. ;
Cave, H. ;
Clappier, E. ;
Mass-Malo, K. ;
Zuna, J. ;
Trka, J. ;
De Braekeleer, E. ;
De Braekeleer, M. ;
Oh, S. H. ;
Tsaur, G. ;
Fechina, L. ;
van der Velden, V. H. J. ;
van Dongen, J. J. M. ;
Delabesse, E. ;
Binato, R. ;
Silva, M. L. M. ;
Kustanovich, A. ;
Aleinikova, O. ;
Harris, M. H. ;
Lund-Aho, T. ;
Juvonen, V. ;
Heidenreich, O. ;
Vormoor, J. ;
Choi, W. W. L. ;
Jarosova, M. ;
Kolenova, A. ;
Bueno, C. ;
Menendez, P. ;
Wehner, S. ;
Eckert, C. ;
Talmant, P. ;
Tondeur, S. ;
Lippert, E. ;
Launay, E. ;
Henry, C. ;
Ballerini, P. ;
Lapillone, H. ;
Callanan, M. B. ;
Cayuela, J. M. ;
Herbaux, C. ;
Cazzaniga, G. .
LEUKEMIA, 2013, 27 (11) :2165-2176
[8]   HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (TALL) [J].
Soulier, J ;
Clappier, E ;
Cayuela, JM ;
Regnault, A ;
García-Peydró, M ;
Dombret, H ;
Baruchel, A ;
Toribio, ML ;
Sigaux, F .
BLOOD, 2005, 106 (01) :274-286
[9]   The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia [J].
Van Vlierberghe, Pieter ;
van Grotel, Martine ;
Tchinda, Joelle ;
Lee, Charles ;
Beverloo, H. Berna ;
van der Spek, Peter J. ;
Stubbs, Andrew ;
Cools, Jan ;
Nagata, Kyosuke ;
Fornerod, Maarten ;
Buijs-Gladdines, Jessica ;
Horstmann, Martin ;
van Wering, Elisabeth R. ;
Soulier, Jean ;
Pieters, Rob ;
Meijerink, Jules P. P. .
BLOOD, 2008, 111 (09) :4668-4680
[10]   Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias [J].
Walker, Christopher J. ;
Oaks, Joshua J. ;
Santhanam, Ramasamy ;
Neviani, Paolo ;
Harb, Jason G. ;
Ferenchak, Gregory ;
Ellis, Justin J. ;
Landesman, Yosef ;
Eisfeld, Ann-Kathrin ;
Gabrail, Nash Y. ;
Smith, Carrie L. ;
Caligiuri, Michael A. ;
Hokland, Peter ;
Roy, Denis Claude ;
Reid, Alistair ;
Milojkovic, Dragana ;
Goldman, John M. ;
Apperley, Jane ;
Garzon, Ramiro ;
Marcucci, Guido ;
Shacham, Sharon ;
Kauffman, Michael G. ;
Perrotti, Danilo .
BLOOD, 2013, 122 (17) :3034-3044