Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data

被引：19
作者：
Yang, Peng [1 ]
Xu, Zi-Peng [1 ]
Chen, Tao [1 ]
He, Zhen-Yu [2 ]
机构：
[1] Nanjing Med Univ, Clin Med Coll 2, Nanjing 210011, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Dept Gen Surg, Affiliated Hosp 2, 121 Jiangjiayuan Rd, Nanjing 210011, Jiangsu, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2016年 / 9卷
关键词：
colorectal cancer; lymph node metastasis; long noncoding RNA; microarray; ENST00000430471; TUMOR-GROWTH; OVEREXPRESSION; LNCRNAS; HOTAIR;
D O I：
10.2147/OTT.S102348
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compared with paired metastatic lymph nodes. Functional prediction showed that lots of lncRNAs might be involved in biological pathways related to CRC metastasis by cis-regulation and trans-regulation of coexpressed genes. As a representative, ENST00000430471 was associated with cell proliferation and invasion of CRC cells. These results provided support for further investigations of the metastatic pathogenesis of CRC.
引用
收藏
页码：2465 / 2478
页数：14
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