Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data

被引：18

作者：

Yang, Peng ^{[1
]}

Xu, Zi-Peng ^{[1
]}

Chen, Tao ^{[1
]}

He, Zhen-Yu ^{[2
]}

机构：

[1] Nanjing Med Univ, Clin Med Coll 2, Nanjing 210011, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Gen Surg, Affiliated Hosp 2, 121 Jiangjiayuan Rd, Nanjing 210011, Jiangsu, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2016年 / 9卷

关键词：

colorectal cancer; lymph node metastasis; long noncoding RNA; microarray; ENST00000430471; TUMOR-GROWTH; OVEREXPRESSION; LNCRNAS; HOTAIR;

D O I：

10.2147/OTT.S102348

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compared with paired metastatic lymph nodes. Functional prediction showed that lots of lncRNAs might be involved in biological pathways related to CRC metastasis by cis-regulation and trans-regulation of coexpressed genes. As a representative, ENST00000430471 was associated with cell proliferation and invasion of CRC cells. These results provided support for further investigations of the metastatic pathogenesis of CRC.

引用

页码：2465 / 2478

页数：14

共 50 条

[21] Long noncoding RNA LINC01510 promotes the growth of colorectal cancer cells by modulating MET expression
Cen, Chaoqun
Li, Jian
Liu, Jingjing
Yang, Mingshi
Zhang, Tianyi
Zuo, Yu
Lin, Changwei
Li, Xiaorong
CANCER CELL INTERNATIONAL, 2018, 18
[22] Microarray expression profile of long noncoding RNAs in human osteosarcoma
Li, Jin-ping
Liu, Li-hong
Li, Jie
Chen, You
Jiang, Xiao-wei
Ouyang, Yu-rong
Liu, Yin-qi
Zhong, Hui
Li, Hui
Xiao, Tao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 433 (02) : 200 - 206
[23] A pilot study of long noncoding RNA expression profiling by microarray in follicular lymphoma
Pan, Yi
Li, Haixin
Guo, Yan
Luo, Ye
Li, Hua
Xu, Yong
Deng, Jingyu
Sun, Baocun
GENE, 2016, 577 (02) : 132 - 139
[24] MICROARRAY EXPRESSION PROFILE ANALYSIS OF LONG NONCODING RNAs IN PREMATURE BRAIN INJURY: A NOVEL POINT OF VIEW
Chen, R. J.
Liu, L.
Xiao, M.
Wang, F.
Lin, X. J.
NEUROSCIENCE, 2016, 319 : 123 - 133
[25] Long noncoding RNA HOTTIP as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis
Chen, Zhicong
He, Anbang
Wang, Dailian
Liu, Yuchen
Huang, Weiren
ONCOTARGET, 2017, 8 (08) : 14126 - 14132
[26] Identification of EGFR expression status association with metastatic lymph node density (ND) by expression microarray analysis of advanced gastric cancer
Ema, Akira
Waraya, Mina
Yamashita, Keishi
Kokubo, Kenichi
Kobayashi, Hirosuke
Hoshi, Keika
Shinkai, Yoshiko
Kawamata, Hiroshi
Nakamura, Kazunori
Nishimiya, Hiroshi
Katada, Natsuya
Watanabe, Masahiko
CANCER MEDICINE, 2015, 4 (01): : 90 - 100
[27] Comprehensive analysis of a long noncoding RNA-associated competing endogenous RNA network in colorectal cancer
Fan, Qiaowei
Liu, Bingrong
ONCOTARGETS AND THERAPY, 2018, 11 : 2453 - 2466
[28] Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancer
Pei, Haiping
Zhu, Hong
Zeng, Shan
Li, Yixiong
Yang, Huixiang
Shen, Liangfang
Chen, Jia
Zeng, Liang
Fan, Jianghong
Li, Xiaogang
Gong, Yuewen
Shen, Hong
JOURNAL OF PROTEOME RESEARCH, 2007, 6 (07) : 2495 - 2501
[29] The long noncoding RNA expression profiles of paroxysmal atrial fibrillation identified by microarray analysis
Su, Ying
Li, Long
Zhao, Sheng
Yue, Yunan
Yang, Shuixiang
GENE, 2018, 642 : 125 - 134
[30] Genome-wide analysis of long noncoding RNA expression profile in papillary thyroid carcinoma
Lan, Xiabin
Zhang, Hao
Wang, Zhihong
Dong, Wenwu
Sun, Wei
Shao, Liang
Zhang, Ting
Zhang, Dalin
GENE, 2015, 569 (01) : 109 - 117

← 1 2 3 4 5 →