Letermovir and HCT: too much of a good thing?

被引：8
作者：
Schleiss, Mark R. [1 ]
机构：
[1] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA
来源：
BLOOD | 2021年 / 138卷 / 01期
关键词：
CYTOMEGALOVIRUS; PROPHYLAXIS;
D O I：
10.1182/blood.2021011459
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Zamora and colleagues address the important issue of cytomegalovirus (CMV) immune constitution following hematopoietic cell transplant (HCT) in patients receiving an antiviral prophylaxis regimen with a novel recently licensed antiviral, letermovir.
引用
收藏
页码：1 / 2
页数：2
相关论文
共 10 条
  • [1] Viral Infections in HSCT: Detection, Monitoring, Clinical Management, and Immunologic Implications
    Annaloro, Claudio
    Serpenti, Fabio
    Saporiti, Giorgia
    Galassi, Giulia
    Cavaliero, Francesca
    Grifoni, Federica
    Goldaniga, Maria
    Baldini, Luca
    Onida, Francesco
    [J]. FRONTIERS IN IMMUNOLOGY, 2021, 11
  • [2] Profiling the Blood Compartment of Hematopoietic Stem Cell Transplant Patients During Human Cytomegalovirus Reactivation
    Bernshtein, Biana
    Nachshon, Aharon
    Shnayder, Miri
    Stern, Lauren
    Avdic, Selmir
    Blyth, Emily
    Gottlieb, David
    Abendroth, Allison
    Slobedman, Barry
    Stern-Ginossar, Noam
    Schwartz, Michal
    [J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 10
  • [3] Valganciclovir for the Prevention of Complications of Late Cytomegalovirus Infection After Allogeneic Hematopoietic Cell Transplantation A Randomized Trial
    Boeckh, Michael
    Nichols, W. Garrett
    Chemaly, Roy F.
    Papanicolaou, Genovefa A.
    Wingard, John R.
    Xie, Hu
    Syrjala, Karen L.
    Flowers, Mary E. D.
    Stevens-Ayers, Terry
    Jerome, Keith R.
    Leisenring, Wendy
    [J]. ANNALS OF INTERNAL MEDICINE, 2015, 162 (01) : 1 - U132
  • [4] How I treat CMV reactivation after allogeneic hematopoietic stem cell transplantation
    Einsele, Hermann
    Ljungman, Per
    Boeckh, Michael
    [J]. BLOOD, 2020, 135 (19) : 1619 - 1629
  • [5] The Novel Anticytomegalovirus Compound AIC246 (Letermovir) Inhibits Human Cytomegalovirus Replication through a Specific Antiviral Mechanism That Involves the Viral Terminase
    Goldner, Thomas
    Hewlett, Guy
    Ettischer, Nicole
    Ruebsamen-Schaeff, Helga
    Zimmermann, Holger
    Lischka, Peter
    [J]. JOURNAL OF VIROLOGY, 2011, 85 (20) : 10884 - 10893
  • [6] Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients
    Ljungman, Per
    Hakki, Morgan
    Boeckh, Michael
    [J]. INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2010, 24 (02) : 319 - +
  • [7] Early Cytomegalovirus Reactivation Leaves a Specific and Dynamic Imprint on the Reconstituting T Cell Compartment Long-Term after Hematopoietic Stem Cell Transplantation
    Lugthart, Gertjan
    van Ostaijen-ten Dam, Monique M.
    Jol-van der Zijde, Cornelia M.
    van Holten, Tessa C.
    Kester, Michel G. D.
    Heemskerk, Mirjam H. M.
    Bredius, Robbert G. M.
    van Toll, Maarten J. D.
    Lankester, Arjan C.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014, 20 (05) : 655 - 661
  • [8] Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation
    Marty, F. M.
    Ljungman, P.
    Chemaly, R. F.
    Maertens, J.
    Dadwal, S. S.
    Duarte, R. F.
    Haider, S.
    Ullmann, A. J.
    Katayama, Y.
    Brown, J.
    Mullane, K. M.
    Boeckh, M.
    Blumberg, E. A.
    Einsele, H.
    Snydman, D. R.
    Kanda, Y.
    DiNubile, M. J.
    Teal, V. L.
    Wan, H.
    Murata, Y.
    Kartsonis, N. A.
    Leavitt, R. Y.
    Badshah, C.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (25) : 2433 - 2444
  • [9] Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors A Randomized Clinical Trial
    Singh, Nina
    Winston, Drew J.
    Razonable, Raymund R.
    Lyon, G. Marshall
    Silveira, Fernanda P.
    Wagener, Marilyn M.
    Stevens-Ayers, Terry
    Edmison, Bradley
    Boeckh, Michael
    Limaye, Ajit P.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (14): : 1378 - 1387
  • [10] Cytomegalovirus-specific T-cell reconstitution following letermovir prophylaxis after hematopoietic cell transplantation
    Zamora, Danniel
    Duke, Elizabeth R.
    Xie, Hu
    Edmison, Bradley C.
    Akoto, Brenda
    Kiener, Richard
    Stevens-Ayers, Terry
    Wagner, Ralf
    Mielcarek, Marco
    Leisenring, Wendy M.
    Jerome, Keith R.
    Schiffer, Joshua T.
    Finak, Greg
    De Rosa, Stephen C.
    Boeckh, Michael
    [J]. BLOOD, 2021, 138 (01) : 34 - 43
1