Whole lesion histogram analysis of meningiomas derived from ADC values. Correlation with several cellularity parameters, proliferation index KI 67, nucleic content, and membrane permeability

被引：37

作者：

Surov, Alexey ^{[1
,2
]}

Hamerla, Gordian ^{[1
]}

Meyer, Hans Jonas ^{[1
]}

Winter, Karsten ^{[3
,4
]}

Schob, Stefan ^{[1
]}

Fiedler, Eckhard ^{[5
]}

机构：

[1] Univ Leipzig, Dept Diagnost & Intervent Radiol, Liebigstr 20, D-04103 Leipzig, Germany

[2] Martin Luther Univ Halle Wittenberg, Dept Radiol, Ernst Grube Str 40, D-06097 Halle, Germany

[3] Univ Leipzig, Inst Neuroanat, Leipzig, Germany

[4] Univ Leipzig, Inst Biometry, Leipzig, Germany

[5] Martin Luther Univ Halle Wittenberg, Dept Dermatol, Halle, Germany

来源：

MAGNETIC RESONANCE IMAGING | 2018年 / 51卷

关键词：

Magnetic resonance imaging; Diffusion weighted imaging; Histogram analysis; KI; 67; Cell count; Meningioma; SQUAMOUS-CELL CARCINOMA; CERVICAL-CANCER; DIFFUSION; ASSOCIATIONS; KI-67; HEAD; EXPERIENCE; FEATURES; ANTIGEN; CYCLE;

D O I：

10.1016/j.mri.2018.05.009

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To analyze several histopathological features and their possible correlations with whole lesion histogram analysis derived from ADC maps in meningioma. Materials and methods: The retrospective study involved 36 patients with primary meningiomas. For every tumor, the following histogram analysis parameters of apparent diffusion coefficient (ADC) were calculated: ADC(mean), ADC(max), ADC(min), ADC(median), ADC(mode), ADC percentiles: P10, P25, P75, P90, as well kurtosis, skewness, and entropy. All measures were performed by two radiologists. Proliferation index K I 67, minimal, maximal and mean cell count, total nucleic area, and expression of water channel aquaporin 4 (AQP4) were estimated. Spearman's correlation coefficient was used to analyze associations between investigated parameters. Results: A perfect interobserver agreement for all ADC values (0.84-0.97) was identified. All ADC values correlated inversely with tumor cellularity with the strongest correlation between P10, P25 and mean cell count (-0.558). KI 67 correlated inversely with all ADC values except ADC(min). ADC parameters did not correlate with total nucleic area. All ADC values correlated statistically significant with expression of AQP4. Conclusions: ADC histogram analysis is a valid method with an excellent interobserver agreement. Cellularity parameters and proliferation potential are associated with different ADC values. Membrane permeability may play a greater role for water diffusion than cell count and proliferation activity.

引用

页码：158 / 162

页数：5