RETRACTED: MiRNA-616 aggravates the progression of bladder cancer by regulating cell proliferation, migration and apoptosis through downregulating SOX7 (Retracted Article)

被引：18
作者：
Zhao, X. [1 ]
Li, D. [1 ]
Zhao, S. -T. [1 ]
Zhang, Y. [1 ]
Xu, A. [1 ]
Hu, Y. -Y. [1 ]
Fang, Z. [1 ]
机构：
[1] Shanghai Tongren Hosp, Dept Urol, Shanghai, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2019年 / 23卷 / 21期
关键词：
MIRNA-616; SOX7; Bladder cancer; TUMOR-SUPPRESSOR; MICRORNA; EXPRESSION; GENES; BIOMARKERS; SIGNATURES; PROSTATE; GROWTH;
D O I：
10.26355/eurrev_201911_19423
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: To investigate the regulatory effect of microRNA-616 (miRNA-616) on cellular behaviors of bladder cancer and the potential mechanism. PATIENTS AND METHODS: The expressions of miRNA-616 and SOX7 in bladder cancer tissues and cell lines were examined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The relationship between miRNA-616 and SOX7 was assessed through Dual-Luciferase Reporter Gene Assay. The regulatory effects of miRNA-616 and SOX7 on cellular behaviors of bladder cancer were evaluated through cell counting kit-8 (CCK-8), colony formation, transwell migration assay, and flow cytometry. RESULTS: MiRNA-616 was upregulated, whereas SOX7 was downregulated in bladder cancer tissues and cell lines. The silence of miRNA-616 attenuated the proliferative and migratory abilities, arrested cell cycle progression in the G2 phase, and stimulated apoptosis in UMUC3 and T24 cells. SOX7 was the target gene of miRNA-616, and its level was negatively regulated by miRNA-616. The knockdown of SOX7 enhanced the proliferative and migratory abilities, and attenuated apoptosis of bladder cancer cells. CONCLUSIONS: MiRNA-616 accelerates bladder cancer cells to proliferate and migrate and inhibits apoptosis by downregulating SOX7. MiRNA-616/SOX7 may be potential therapeutic targets for bladder cancer.
引用
收藏
页码：9304 / 9312
页数：9
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