RETRACTED: MiRNA-616 aggravates the progression of bladder cancer by regulating cell proliferation, migration and apoptosis through downregulating SOX7 (Retracted Article)

被引：18

作者：

Zhao, X. ^{[1
]}

Li, D. ^{[1
]}

Zhao, S. -T. ^{[1
]}

Zhang, Y. ^{[1
]}

Xu, A. ^{[1
]}

Hu, Y. -Y. ^{[1
]}

Fang, Z. ^{[1
]}

机构：

[1] Shanghai Tongren Hosp, Dept Urol, Shanghai, Peoples R China

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2019年 / 23卷 / 21期

关键词：

MIRNA-616; SOX7; Bladder cancer; TUMOR-SUPPRESSOR; MICRORNA; EXPRESSION; GENES; BIOMARKERS; SIGNATURES; PROSTATE; GROWTH;

D O I：

10.26355/eurrev_201911_19423

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: To investigate the regulatory effect of microRNA-616 (miRNA-616) on cellular behaviors of bladder cancer and the potential mechanism. PATIENTS AND METHODS: The expressions of miRNA-616 and SOX7 in bladder cancer tissues and cell lines were examined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The relationship between miRNA-616 and SOX7 was assessed through Dual-Luciferase Reporter Gene Assay. The regulatory effects of miRNA-616 and SOX7 on cellular behaviors of bladder cancer were evaluated through cell counting kit-8 (CCK-8), colony formation, transwell migration assay, and flow cytometry. RESULTS: MiRNA-616 was upregulated, whereas SOX7 was downregulated in bladder cancer tissues and cell lines. The silence of miRNA-616 attenuated the proliferative and migratory abilities, arrested cell cycle progression in the G2 phase, and stimulated apoptosis in UMUC3 and T24 cells. SOX7 was the target gene of miRNA-616, and its level was negatively regulated by miRNA-616. The knockdown of SOX7 enhanced the proliferative and migratory abilities, and attenuated apoptosis of bladder cancer cells. CONCLUSIONS: MiRNA-616 accelerates bladder cancer cells to proliferate and migrate and inhibits apoptosis by downregulating SOX7. MiRNA-616/SOX7 may be potential therapeutic targets for bladder cancer.

引用

页码：9304 / 9312

页数：9

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