Benzophenone C- and O-Glucosides from Cyclopia genistoides (Honeybush) Inhibit Mammalian α-Glucosidase

被引：47

作者：

Beelders, Theresa ^{[1
,2
]}

Brand, D. Jacobus ^{[3
]}

de Beer, Dalene

Malherbe, Christiaan J. ^{[2
]}

Mazibuko, Sithandiwe E. ^{[4
]}

Muller, Christo J. F. ^{[4
]}

Joubert, Elizabeth ^{[1
,2
]}

机构：

[1] Univ Stellenbosch, Dept Food Sci, ZA-7602 Matieland, South Africa

[2] ARC Infruitec Nietvoorbij, Postharvest & Wine Technol Div, ZA-7599 Stellenbosch, South Africa

[3] Nucl Magnet Resonance Unit, CAF, ZA-7602 Matieland, South Africa

[4] South African Med Res Council, Diabet Discovery Platform, ZA-7505 Tygerberg, South Africa

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 12期

关键词：

ANTIOXIDANT CAPACITY; L; VENT; XANTHONE; CONSTITUENTS; DERIVATIVES; MANGIFERIN; EXTRACT; MS;

D O I：

10.1021/np5007247

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An enriched fraction of an aqueous extract prepared from the aerial parts of Cyclopia genistoides Vent. yielded a new benzophenone di-C,O-glucoside, 3-C-β-d-glucopyranosyl-4-O-β-d-glucopyranosyliriflophenone (1), together with small quantities of a known benzophenone C-glucoside, 3-C-β-d-glucopyranosylmaclurin (2). The isolated compounds showed α-glucosidase inhibitory activity against an enzyme mixture extracted from rat intestinal acetone powder. Compound 2 exhibited significantly (p < 0.05) higher inhibitory activity (54%) than 1 (43%) at 200 μM. In vitro tests in several cell models showed that 1 and its 3-C-monoglucosylated derivative (3-C-β-d-glucopyranosyliriflophenone) were marginally effective (p ≥ 0.05) in increasing glucose uptake. © 2014 The American Chemical Society and American Society of Pharmacognosy.

引用

页码：2694 / 2699

页数：6

共 5 条

[1] Cleavage of S/O-glucosides by β-glucosidase from sweet almond
Shen, Hong
Byers, Larry D.
FASEB JOURNAL, 2008, 22
[2] Simultaneous optimisation of extraction of xanthone and benzophenone α-glucosidase inhibitors from Cyclopia genistoides and identification of superior genotypes for propagation
Bosman, Stephanie C.
de Beer, Dalene
Beelders, Theresa
Willenburg, Elize L.
Malherbe, Christiaan J.
Walczak, Beata
Joubert, Elizabeth
JOURNAL OF FUNCTIONAL FOODS, 2017, 33 : 21 - 31
[3] Intestinal Bacterium Eubacterium cellulosolvens Deglycosylates Flavonoid C- and O-Glucosides
Braune, Annett
Blaut, Michael
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2012, 78 (22) : 8151 - 8153
[4] Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis
Kokotkiewicz, Adam
Luczkiewicz, Maria
Pawlowska, Justyna
Luczkiewicz, Piotr
Sowinski, Pawel
Witkowski, Jacek
Bryl, Ewa
Bucinski, Adam
FITOTERAPIA, 2013, 90 : 199 - 208
[5] Identification, purification and characterization of β-glucosidase from apple seed as a novel catalyst for synthesis of O-glucosides
Yu, Hui-Lei
Xu, Jian-He
Lu, Wen-Ya
Lin, Guo-Qiang
ENZYME AND MICROBIAL TECHNOLOGY, 2007, 40 (02) : 354 - 361

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