Benzophenone C- and O-Glucosides from Cyclopia genistoides (Honeybush) Inhibit Mammalian α-Glucosidase

被引：47

作者：

Beelders, Theresa ^{[1
,2
]}

Brand, D. Jacobus ^{[3
]}

de Beer, Dalene

Malherbe, Christiaan J. ^{[2
]}

Mazibuko, Sithandiwe E. ^{[4
]}

Muller, Christo J. F. ^{[4
]}

Joubert, Elizabeth ^{[1
,2
]}

机构：

[1] Univ Stellenbosch, Dept Food Sci, ZA-7602 Matieland, South Africa

[2] ARC Infruitec Nietvoorbij, Postharvest & Wine Technol Div, ZA-7599 Stellenbosch, South Africa

[3] Nucl Magnet Resonance Unit, CAF, ZA-7602 Matieland, South Africa

[4] South African Med Res Council, Diabet Discovery Platform, ZA-7505 Tygerberg, South Africa

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 12期

关键词：

ANTIOXIDANT CAPACITY; L; VENT; XANTHONE; CONSTITUENTS; DERIVATIVES; MANGIFERIN; EXTRACT; MS;

D O I：

10.1021/np5007247

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An enriched fraction of an aqueous extract prepared from the aerial parts of Cyclopia genistoides Vent. yielded a new benzophenone di-C,O-glucoside, 3-C-β-d-glucopyranosyl-4-O-β-d-glucopyranosyliriflophenone (1), together with small quantities of a known benzophenone C-glucoside, 3-C-β-d-glucopyranosylmaclurin (2). The isolated compounds showed α-glucosidase inhibitory activity against an enzyme mixture extracted from rat intestinal acetone powder. Compound 2 exhibited significantly (p < 0.05) higher inhibitory activity (54%) than 1 (43%) at 200 μM. In vitro tests in several cell models showed that 1 and its 3-C-monoglucosylated derivative (3-C-β-d-glucopyranosyliriflophenone) were marginally effective (p ≥ 0.05) in increasing glucose uptake. © 2014 The American Chemical Society and American Society of Pharmacognosy.

引用

页码：2694 / 2699

页数：6

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