Copper-Catalyzed Direct Oxidative α-Alkoxylation of 4-Isochromanones

被引：1
作者：
Wu, Xiang [1 ]
Song, Shuang-Gui [1 ]
Zhang, Xin [1 ]
Fu, Yan-Ming [1 ]
Zhu, Cheng-Feng [1 ]
Li, You-Gui [1 ]
机构：
[1] Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Adv Catalyt Mat & React Engn, 193 Tunxi Rd, Hefei 230009, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 17期
基金：
中国国家自然科学基金;
关键词：
Alkoxylation; C-O bond; Copper; Oxidative cross-coupling; 3-Oxy-4-isochromanones; KETONES;
D O I：
10.1002/ejoc.202100243
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct oxidative alpha-alkoxylation of carbonyl compounds is very important, highly desirable but relatively rare. A general and convenient approach has been developed to prepare 3-oxy-4-isochromanones by copper-catalyzed alpha-C(sp(3))-H alkoxylation of 4-isochromanones with alcohols. The key features are easily available starting materials, mild reaction conditions, broad substrate scope, and excellent regioselectivity.
引用
收藏
页码：2436 / 2439
页数：4
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