The role of the gut and microbes in the pathogenesis of spondyloarthritis

被引：78

作者：

Asquith, Mark ^{[1
,2
]}

Elewaut, Dirk ^{[3
]}

Lin, Phoebe ^{[1
,2
]}

Rosenbaum, James T. ^{[1
,2
,4
]}

机构：

[1] Oregon Hlth & Sci Univ, Div Arthrit & Rheumat Dis, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR 97239 USA

[3] Ghent Univ Hosp, Dept Rheumatol, B-9000 Ghent, Belgium

[4] Legacy Devers Eye Inst, Portland, OR 97210 USA

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2014年 / 28卷 / 05期

关键词：

Microbiota; Dysbiosis; Spondyloarthritis; Ankylosing spondylitis; Reactive arthritis; Inflammatory bowel disease; INNATE LYMPHOID-CELLS; HLA-B27 TRANSGENIC RATS; INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; INTESTINAL INFLAMMATION; ANKYLOSING-SPONDYLITIS; AXIAL SPONDYLOARTHRITIS; REACTIVE ARTHRITIS; CHRONIC COLITIS; IN-VIVO;

D O I：

10.1016/j.berh.2014.10.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The intestinal microbiota is firmly implicated not only in the pathogenesis of inflammatory bowel disease (IBD) but increasingly also in the development of inflammation at extraintestinal tissue sites. Significant clinical, genetic, immunological, and microbiological overlap exists between IBD and spondyloarthritis (SpA), which indicates that pathophysiological mechanisms are shared between these diseases and may center on the intestinal microbiota. Recently, culture-independent techniques have enabled the microbiota in health and disease to be described in increasing detail. Moreover, functional studies have identified myriad host effector and regulatory pathways that shape or are shaped by this microbial community. We consider the complex relationship between SpA pathogenesis and gut microbes, with a discussion of how manipulation of the gut microbiota itself may be a promising future target for SpA therapy. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：687 / 702

页数：16

共 102 条

[41] Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria [J].

Hepworth, Matthew R. ;

Monticelli, Laurel A. ;

Fung, Thomas C. ;

Ziegler, Carly G. K. ;

Grunberg, Stephanie ;

Sinha, Rohini ;

Mantegazza, Adriana R. ;

Ma, Hak-Ling ;

Crawford, Alison ;

Angelosanto, Jill M. ;

Wherry, E. John ;

Koni, Pandelakis A. ;

Bushman, Frederic D. ;

Elson, Charles O. ;

Eberl, Gerard ;

Artis, David ;

Sonnenberg, Gregory F. .

NATURE, 2013, 498 (7452) :113-+

[42] SALMONELLA-REACTIVE SYNOVIAL-FLUID T-CELL CLONES IN A PATIENT WITH POSTINFECTIOUS SALMONELLA ARTHRITIS [J].

HERMANN, E ;

MAYET, WJ ;

PORALLA, T ;

ZUMBUSCHENFELDE, KHM ;

FLEISCHER, B .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1990, 19 (05) :350-355

[43] INFLAMMATORY BOWEL-DISEASE AND ADENOMAS IN MICE EXPRESSING A DOMINANT-NEGATIVE N-CADHERIN [J].

HERMISTON, ML ;

GORDON, JI .

SCIENCE, 1995, 270 (5239) :1203-1207

[44] Reduction of colitis by prebiotics in HLA-1327 transgenic rats is associated with microflora changes and immunomodulation [J].

Hoentjen, F ;

Welling, GW ;

Harmsen, HJM ;

Zhang, XY ;

Snart, J ;

Tannock, GW ;

Lien, K ;

Churchill, TA ;

Lupicki, M ;

Dieleman, LA .

INFLAMMATORY BOWEL DISEASES, 2005, 11 (11) :977-985

[45] Inflammatory Bowel Disease as a Model for Translating the Microbiome [J].

Huttenhower, Curtis ;

Kostic, Aleksandar D. ;

Xavier, Ramnik J. .

IMMUNITY, 2014, 40 (06) :843-854

[46] Structure, function and diversity of the healthy human microbiome [J].

Huttenhower, Curtis ;

Gevers, Dirk ;

Knight, Rob ;

Abubucker, Sahar ;

Badger, Jonathan H. ;

Chinwalla, Asif T. ;

Creasy, Heather H. ;

Earl, Ashlee M. ;

FitzGerald, Michael G. ;

Fulton, Robert S. ;

Giglio, Michelle G. ;

Hallsworth-Pepin, Kymberlie ;

Lobos, Elizabeth A. ;

Madupu, Ramana ;

Magrini, Vincent ;

Martin, John C. ;

Mitreva, Makedonka ;

Muzny, Donna M. ;

Sodergren, Erica J. ;

Versalovic, James ;

Wollam, Aye M. ;

Worley, Kim C. ;

Wortman, Jennifer R. ;

Young, Sarah K. ;

Zeng, Qiandong ;

Aagaard, Kjersti M. ;

Abolude, Olukemi O. ;

Allen-Vercoe, Emma ;

Alm, Eric J. ;

Alvarado, Lucia ;

Andersen, Gary L. ;

Anderson, Scott ;

Appelbaum, Elizabeth ;

Arachchi, Harindra M. ;

Armitage, Gary ;

Arze, Cesar A. ;

Ayvaz, Tulin ;

Baker, Carl C. ;

Begg, Lisa ;

Belachew, Tsegahiwot ;

Bhonagiri, Veena ;

Bihan, Monika ;

Blaser, Martin J. ;

Bloom, Toby ;

Bonazzi, Vivien ;

Brooks, J. Paul ;

Buck, Gregory A. ;

Buhay, Christian J. ;

Busam, Dana A. ;

Campbell, Joseph L. .

NATURE, 2012, 486 (7402) :207-214

[47] Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease [J].

Ishikawa, D. ;

Okazawa, A. ;

Corridoni, D. ;

Jia, L. G. ;

Wang, X. M. ;

Guanzon, M. ;

Xin, W. ;

Arseneau, K. O. ;

Pizarro, T. T. ;

Cominelli, F. .

MUCOSAL IMMUNOLOGY, 2013, 6 (02) :267-275

[48] Joint expedition: linking gut inflammation to arthritis [J].

Jacques, P. ;

Elewaut, D. .

MUCOSAL IMMUNOLOGY, 2008, 1 (05) :364-371

[49] Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells [J].

Jacques, Peggy ;

Lambrecht, Stijn ;

Verheugen, Eveline ;

Pauwels, Elin ;

Kollias, George ;

Armaka, Maria ;

Verhoye, Marleen ;

Van der Linden, Annemie ;

Achten, Rik ;

Lories, Rik J. ;

Elewaut, Dirk .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (02) :437-445

[50] Invariant Natural Killer T Cells Are Natural Regulators of Murine Spondylarthritis [J].

Jacques, Peggy ;

Venken, Koen ;

Van Beneden, Katrien ;

Hammad, Hamida ;

Seeuws, Sylvie ;

Drennan, Michael B. ;

Deforce, Dieter ;

Verbruggen, Gust ;

Apostolaki, Maria ;

Kollias, George ;

Lambrecht, Bart N. ;

De Vos, Martine ;

Elewaut, Dirk .

ARTHRITIS AND RHEUMATISM, 2010, 62 (04) :988-999

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