Nardochinoids A-C, Three Dimeric Sesquiterpenoids with Specific Fused-Ring Skeletons from Nardostachys chinensis

被引：20

作者：

Shen, Xiu-Yu ^{[1
]}

Qin, Da-Peng ^{[2
,3
]}

Zhou, Hua ^{[4
,5
]}

Luo, Jin-Fang ^{[4
,5
]}

Yao, Yun-Da ^{[4
,5
]}

Lio, Chon-Kit ^{[4
,5
]}

Li, Hai-Bo ^{[2
,3
]}

Dai, Yi ^{[2
,3
]}

Yu, Yang ^{[2
,3
]}

Yao, Xin-Sheng ^{[1
,2
,3
]}

机构：

[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China

[4] Macau Univ Sci & Technol, Fac Chinese Med, Taipa, Macau, Peoples R China

[5] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 18期

基金：

中国国家自然科学基金;

关键词：

NARDOSINANE-TYPE SESQUITERPENOIDS; GUAIANE-TYPE; ROOTS; DINARDOKANSHONES; JATAMANSI; RHIZOMES;

D O I：

10.1021/acs.orglett.8b02511

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three unusual sesquiterpenoid dimers, nardochinoids A-C (1-3), were isolated from Nardostachys chinensis Batal. Comyound 1 features a rare fused 3,8-dioxatricyclo [7.2.1.0(1,6)]dodecane-11-one ring system, compound 2 is the first nitrogen-containing nornardosinane-aristolane sesquiterpene conjugate, and compound 3 represents the first example of the dimer of a nornardosinane and a nardosinane sesquiterpene. Their structures were characterized by NMR spectroscopic methods and X-ray single-crystal diffraction analysis. Compound 3 showed significant anti-inflammatory activities.

引用

页码：5813 / 5816

页数：4

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