Interaction of arsenic compounds with model phospholipid membranes

被引：10
作者：
Jemiola-Rzeminska, Malgorzata
Rivera, Cecilia
Suwalsky, Mario
Strzalka, Kazimierz
机构：
[1] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, PL-30387 Krakow, Poland
[2] Univ Concepcion, Fac Chem Sci, Concepcion, Chile
来源：
THERMOCHIMICA ACTA | 2007年 / 458卷 / 1-2期
关键词：
sodium arsenite; sodium arsenate; cacodylic acid; phospholipid bilayer; phase transition; differential scanning calorimetry;
D O I：
10.1016/j.tca.2007.01.004
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
This study is part of a project aimed at examining the influence of arsenic on biological membranes. By the use of differential scanning calorimetry (DSC) we have followed the thermotropic behavior of multilamellar vesicles prepared from dimyristoylphosphatidyleholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE) upon incorporation of sodium arsenite (AsI), disodium arsenate (AsII), cacodylic acid (AsIII) and disodium methyl arsenate (AsIV). The effectiveness of perturbations exerted by various arsenic compounds on thermotropic phase transition was further analysed in terms of thermodynamic parameters: transition temperature, enthalpy and molar heat capacity, determined for lipid/As systems on the basis of heating and cooling scans. It is found that while it only has a slight influence on the thermotropic properties of DMPC, arsenic is able to significantly modify DMPE model membranes. (C) 2007 Elsevier B.V. All rights reserved.
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收藏
页码：132 / 137
页数：6
相关论文
共 26 条
[1]  
[Anonymous], BIOMMBRANE STRUCTURE
[2]   DMPS -: Arsenic Challenge Test II.: Modulation of arsenic species, including monomethylarsonous acid (MMAIII), excreted in human urine [J].
Aposhian, HV ;
Zheng, BS ;
Aposhian, MM ;
Le, XC ;
Cebrian, ME ;
Cullen, W ;
Zakharyan, RA ;
Ma, HS ;
Dart, RC ;
Cheng, Z ;
Andrewes, P ;
Yip, L ;
O'Malley, GF ;
Maiorino, RM ;
Van Voorhies, W ;
Healy, SM ;
Titcomb, A .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2000, 165 (01) :74-83
[3]   CALORIMETRIC STUDIES OF STRUCTURAL TRANSITIONS OF HUMAN ERYTHROCYTE-MEMBRANE - INVOLVEMENT OF SPECTRIN IN A-TRANSITION [J].
BRANDTS, JF ;
ERICKSON, L ;
LYSKO, K ;
SCHWARTZ, AT ;
TAVERNA, RD .
BIOCHEMISTRY, 1977, 16 (15) :3450-3454
[4]   Effect of inhalation anaesthetics on the phase behaviour, permeability and order of phosphatidylcholine bilayers [J].
Engelke, M ;
Jessel, R ;
Wiechmann, A ;
Diehl, HA .
BIOPHYSICAL CHEMISTRY, 1997, 67 (1-3) :127-138
[5]   Calorimetric and molecular mechanics studies of the thermotropic phase behavior of membrane phospholipids [J].
Huang, CH ;
Li, SS .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON BIOMEMBRANES, 1999, 1422 (03) :273-307
[6]   Arsenic toxicity and potential mechanisms of action [J].
Hughes, MF .
TOXICOLOGY LETTERS, 2002, 133 (01) :1-16
[7]   CALORIMETRIC STUDY OF PROTEIN TRANSITIONS IN HUMAN ERYTHROCYTE GHOSTS [J].
JACKSON, WM ;
KOSTYLA, J ;
NORDIN, JH ;
BRANDTS, JF .
BIOCHEMISTRY, 1973, 12 (19) :3662-3667
[8]   The influence of structure and redox state of prenylquinones on thermotropic phase behaviour of phospholipids in model membranes [J].
Jemiola-Rzeminska, M ;
Mysliwa-Kurdziel, B ;
Strzalka, K .
CHEMISTRY AND PHYSICS OF LIPIDS, 2002, 114 (02) :169-180
[9]  
KENNEY LJ, 1988, J BIOL CHEM, V263, P7954
[10]   Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites [J].
Kitchin, KT .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2001, 172 (03) :249-261
123