Synthesis and Structure Control of L-Lactic Acid-Glycolic Acid Copolymer by Homo-Copolymerization

被引：12
作者：
Yin, Huihui [1 ]
Wang, Rui [1 ,2 ]
Ge, Huan [2 ]
Zhang, Xiuqin [2 ]
Zhu, Zhiguo [2 ]
机构：
[1] Sichuan Univ, Dept Polymer Sci & Mat, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China
[2] Beijing Inst Fash Technol, Dept Mat Sci & Engn, Beijing 100029, Peoples R China
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2015年 / 132卷 / 09期
关键词：
biomaterials; crystallization; polycondensation; thermal properties; thermogravimetric analysis (TGA); DIRECT MELT POLYCONDENSATION; RING-OPENING POLYMERIZATION; EPSILON-CAPROLACTONE; POLY(LACTIC ACID); POLY(BUTYLENE TEREPHTHALATE); POLY(L-LACTIC ACID); THERMAL-STABILITY; BULK REACTION; DEGRADATION; ACETYLACETONATE;
D O I：
10.1002/app.41566
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A two-step direct melt copolymerization process of l-lactic acid (L-LA)/glycolic acid (GA) was developed: poly(l-lactic acid) (PLLA) and poly(glycolic acid) (PGA) with different molecular weight was first synthesized respectively by binary catalyst (tin chloride/p-toluenesulfonic or tin chloride); and then poly(l-lactic-co-glycolic acid) (b-PLGA) was produced by melt polymerization of the as-prepared PLLA and PGA, wherein the composition and chain structure of b-PLGA copolymers could be controlled by the molecular weight of PLLA. The chain structure and thermal properties of copolymers were studied by Wide-angle X-ray diffraction, nuclear magnetic resonance, differential scanning calorimetry, and thermogravimetric analysis. In comparison with the random PLGA (r-PLGA) synthesized by one-step direct melt polymerization, the average l-lactic blocks length (L-LA) in b-PLGA was longer while the average glycolic blocks length (L-GA) in b-PLGA was shorter which further resulted in the improved crystallinity and thermostability. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41566.
引用
收藏
页数：6
相关论文
共 36 条
[1]  
Babanalbandi A, 1999, POLYM INT, V48, P980, DOI 10.1002/(SICI)1097-0126(199910)48:10<980::AID-PI257>3.0.CO
[2]  
2-B
[3]   Application of zirconium (IV) acetylacetonate to the copolymerization of glycolide with ε-caprolactone and lactide [J].
Bero, M ;
Dobrzynski, P ;
Kasperczyk, J .
POLYMER BULLETIN, 1999, 42 (02) :131-139
[4]   Old polymer learns new tracts [J].
Campolongo, Michael J. ;
Luo, Dan .
NATURE MATERIALS, 2009, 8 (06) :447-448
[5]   Melting bulk reaction between poly(butylene terephthalate) and poly(ethylene glycol)/DL-oligo(lactic acid) [J].
Chen, Yiwang ;
Zhu, Xiangjun ;
Tan, Licheng ;
Su, Jiying .
JOURNAL OF APPLIED POLYMER SCIENCE, 2008, 108 (04) :2171-2179
[6]   Controlled ring-opening polymerization of lactide and glycolide [J].
Dechy-Cabaret, O ;
Martin-Vaca, B ;
Bourissou, D .
CHEMICAL REVIEWS, 2004, 104 (12) :6147-6176
[7]   Application of calcium acetylacetonate to the polymerization of glycolide and copolymerization of glycolide with ε-caprolactone and L-lactide [J].
Dobrzynski, P ;
Kasperczyk, J ;
Bero, M .
MACROMOLECULES, 1999, 32 (14) :4735-4737
[8]   Synthesis of biodegradable glycolide/L-lactide copolymers using iron compounds as initiators [J].
Dobrzynski, P ;
Kasperczyk, J ;
Janeczek, H ;
Bero, M .
POLYMER, 2002, 43 (09) :2595-2601
[9]   Synthesis of biodegradable copolymers with the use of low toxic zirconium compounds.: 1.: Copolymerization of glycolide with L-lactide initiated by Zr(Acac)4 [J].
Dobrzynski, P ;
Kasperczyk, J ;
Janeczek, H ;
Bero, M .
MACROMOLECULES, 2001, 34 (15) :5090-5098
[10]   Recent Developments in Metal-Catalyzed Ring-Opening Polymerization of Lactides and Glycolides: Preparation of Polylactides, Polyglycolide, and Poly(lactide-co-glycolide) [J].
Dutta, Saikat ;
Hung, Wen-Chou ;
Huang, Bor-Hunn ;
Lin, Chu-Chieh .
SYNTHETIC BIODEGRADABLE POLYMERS, 2012, 245 :219-283
1234