Safe Scale-Up of Pharmaceutical Manufacturing Processes with Dimethyl Sulfoxide as the Solvent and a Reactant or a Byproduct

被引：30

作者：

Wang, Zhe ^{[1
]}

Richter, Steven M. ^{[1
]}

Bellettini, John R. ^{[1
]}

Pu, Yu-Ming ^{[1
]}

Hill, David R. ^{[1
]}

机构：

[1] AbbVie Inc, Proc Res & Dev, N Chicago, IL 60064 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2014年 / 18卷 / 12期

关键词：

DMSO;

D O I：

10.1021/op500260n

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Thermal hazard analyses of two reactions, one with DMSO as the solvent and a reactant and one with DMSO as the solvent and a byproduct, identified low-probability but severe consequence process risks associated with violent decomposition of DMSO during heating control failure or external heating. Although DMSO cannot be totally eliminated from these reactions, using an alternative solvent to replace DMSO proved to be an effective measure in reducing the thermal hazards to allow safe scale-up.

引用

收藏

页码：1836 / 1842

页数：7

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