Novel Diagnostic and Prognostic Modalities in Inflammatory Bowel Disease (Reprinted from Gastroenterology Clinics of North America, vol 38)

被引:4
作者
Zisman, Timothy L. [2 ]
Rubin, David T. [1 ]
机构
[1] Univ Chicago, Med Ctr, Ctr Inflammatory Bowel Dis, Chicago, IL 60637 USA
[2] Univ Washington, Div Gastroenterol, Med Ctr, Seattle, WA 98195 USA
关键词
Inflammatory bowel disease; Diagnosis; Prognosis; Serologies; Imaging; Fecal biomarkers; ANTI-SACCHAROMYCES-CEREVISIAE; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; C-REACTIVE PROTEIN; POUCH-ANAL ANASTOMOSIS; PRIMARY SCLEROSING CHOLANGITIS; GRANULOCYTE MARKER PROTEIN; DOUBLE-BALLOON ENTEROSCOPY; SEVERE ULCERATIVE-COLITIS; CROHNS-DISEASE; FECAL CALPROTECTIN;
D O I
10.1016/j.mcna.2009.10.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inflammatory bowel disease remains a complex disease with variable clinical presentations and often nonspecific symptoms. Physicians must rely on diagnostic tools for clarification of disease diagnosis and for guiding management of patients with established disease. Advances in radiologic imaging modalities facilitate early and accurate detection of luminal disease and extraluminal complications. The introduction and dissemination of small bowel capsule endoscopy and double-balloon enteroscopy permit detailed visualization and sampling of the mucosa throughout the entire bowel. Serologic biomarkers are evolving as a valuable tool to clarify diagnosis and stratify patients by disease phenotypes and patterns of behavior. Neutrophil-derived fecal biomarkers are emerging as useful surrogate markers of intestinal inflammation with the potential for a variety of clinical applications, but their application to clinical management has not yet been clarified.
引用
收藏
页码:155 / +
页数:25
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