Ruthenium(II)-catalyzed α-fluoroalkenylation of arenes via C-H bond activation and C-F bond cleavage

被引：32

作者：

Li, Na ^{[1
,2
]}

Chang, Junbiao ^{[1
]}

Kong, Lingheng ^{[3
]}

Li, Xingwei ^{[1
,3
]}

机构：

[1] Henan Normal Univ, Sch Chem & Chem Engn, Henan Key Lab Organ Funct Mol & Drug Innovat, Xinxiang 453007, Peoples R China

[2] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Peoples R China

[3] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 12期

关键词：

METAL-COMPLEXES; GEM-DIFLUOROALKENES; ARYL FLUORIDES; ANTICANCER AGENTS; FUNCTIONALIZATION; FLUORINATION; CATALYSIS; ACCESS; MONOFLUOROALKENYLATION; TRIFLUOROMETHYLATION;

D O I：

10.1039/c8qo00297e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ru(II)-Catalyzed efficient alpha-fluoroalkenylation of arenes has been realized with gem-difluorostyrene as an olefinating reagent. This coupling system is efficient with a broad substrate scope, providing 1,2-diaryl-substituted monofluoroalkenes with good to excellent regio- and stereoselectivities under silver-free conditions.

引用

页码：1978 / 1982

页数：5

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