COMPARISON OF 18F-FLUOROTHYMIDINE AND 18F-FLUORODEOXYGLUCOSE PET/CT IN DELINEATING GROSS TUMOR VOLUME BY OPTIMAL THRESHOLD IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THORACIC ESOPHAGUS

被引：79

作者：

Han, Dali ^{[1
]}

Yu, Jinming ^{[1
]}

Yu, Yonghua ^{[1
]}

Zhang, Guifang ^{[1
]}

Zhong, Xaojun ^{[1
]}

Lu, Jie ^{[1
]}

Yin, Yong ^{[1
]}

Fu, Zheng ^{[2
]}

Mu, Dianbin ^{[3
]}

Zhang, Baijiang ^{[4
]}

He, Wei ^{[1
]}

Huo, Zhijun ^{[1
]}

Liu, Xijun ^{[1
]}

Kong, Lei ^{[1
]}

Zhao, Shuqiang ^{[2
]}

Sun, Xiangyu ^{[3
]}

机构：

[1] Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Shandong Prov, Peoples R China

[2] Shandong Canc Hosp & Inst, Dept Nucl Med, Jinan 250117, Shandong Prov, Peoples R China

[3] Shandong Canc Hosp & Inst, Dept Pathol, Jinan 250117, Shandong Prov, Peoples R China

[4] Shandong Canc Hosp & Inst, Dept Thorac Surg, Jinan 250117, Shandong Prov, Peoples R China

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2010年 / 76卷 / 04期

关键词：

Esophageal carcinoma; positron emission tomography; radiotherapy; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET; RADIOTHERAPY; CANCER; CT; RECURRENCE; F-18-FDG;

D O I：

10.1016/j.ijrobp.2009.07.1681

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To determine the optimal method of using F-18-fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) simulation to delineate the gross tumor volume (GTV) in esophageal squamous cell carcinoma verified by pathologic examination and compare the results with those using F-18-fluorodeoxyglucose (FDG) PET/CT. Methods and Materials: A total of 22 patients were enrolled and underwent both FLT and FDG PET/CT. The GTVs with biologic information were delineated using seven different methods in FLT PET/CT and three different methods in FDG PET/CT. The results were compared with the pathologic gross tumor length, and the optimal threshold was obtained. Next, we compared the simulation plans using the optimal threshold of FLT and FDG PET/CT. The radiation dose was prescribed as 60 Gy in 30 fractions with a precise radiotherapy technique. Results: The mean standard deviation pathologic gross tumor length was 4.94 +/- 2.21 cm. On FLT PET/CT, the length of the standardized uptake value 1.4 was 4.91 +/- 2.43 cm. On FDG PET/CT, the length of the standardized uptake value 2.5 was 5.10 +/- 2.18 cm, both of which seemed more approximate to the pathologic gross tumor length. The differences in the bilateral lung volume receiving >= 20 Gy, heart volume receiving 40 Gy, and the maximal dose received by spinal cord between FLT and FDG were not significant. However, the values for mean lung dose, bilateral lung volume receiving and Gy, mean heart dose, and heart volume receiving >= 30 Gy using FLT PET/CT-based planning were significant lower than those using FDG PET/CT. Conclusion: A standardized uptake value cutoff of 1.4 on FLT PET/CT and one of 2.5 on FDG PET/CT provided the closest estimation of GTV length. Finally, FLT PET/CT-based treatment planning provided potential benefits to the lungs and heart. (C) 2010 Elsevier Inc.

引用

页码：1235 / 1241

页数：7

共 17 条

[1]

Arslan Nuri, 2002, Mol Imaging Biol, V4, P301, DOI 10.1016/S1536-1632(02)00011-2

[2] STUDY TO DETERMINE ADEQUATE MARGINS IN RADIOTHERAPY PLANNING FOR ESOPHAGEAL CARCINOMA BY DETAILING PATTERNS OF RECURRENCE AFTER DEFINITIVE CHEMORADIOTHERAPY [J].

Button, Michael R. ;

Morgan, Carys A. ;

Croydon, Elizabeth S. ;

Roberts, S. Ashley ;

Crosby, Thomas D. L. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 73 (03) :818-823

[3] Tumor volume in pharyngolaryngeal squamous cell carcinoma:: Comparison at CT, MR imaging, and FDG PET and validation with surgical specimen [J].

Daisne, JF ;

Duprez, T ;

Weynand, B ;

Lonneux, M ;

Hamoir, M ;

Reychler, H ;

Grégoire, V .

RADIOLOGY, 2004, 233 (01) :93-100

[4] Pathological analysis of clinical target volume margin for radiotherapy in patients with esophageal and gastroesophageal junction carcinoma [J].

Gao, Xian-Shu ;

Qiao, Xueying ;

Wu, Fengpeng ;

Cao, Li ;

Meng, Xianli ;

Dong, Zhiming ;

Wang, Xiaoling ;

Gao, Guodong ;

Wu, Tsung-Teh ;

Komaki, Ritsuko ;

Chang, Joe Y. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 67 (02) :389-396

[5] Diagnostic and prognostic value of 18F-FDG PET/CT for patients with suspected recurrence from squamous cell carcinoma of the esophagus [J].

Guo, Hongbo ;

Zhu, Hui ;

Xi, Yan ;

Zhang, Baijiang ;

Li, Ling ;

Huang, Yong ;

Zhang, Jiandong ;

Fu, Zheng ;

Yang, Guoren ;

Yuan, Shuanghu ;

Yu, Jinming .

JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (08) :1251-1258

[6] Considerations in treatment planning for esophageal cancer [J].

Hong, Theodore S. ;

Crowley, Elizabeth M. ;

Killoran, Joseph ;

Mamon, Harvey J. .

SEMINARS IN RADIATION ONCOLOGY, 2007, 17 (01) :53-61

[7]

KUBOTA R, 1992, J NUCL MED, V33, P1972

[8]

LU JJ, 2008, ESOPHAGEAL CANC RAD, P182

[9]

Ma Guo-Wei, 2004, Ai Zheng, V23, P193

[10] Impact of CT and 18F-deoxyglucose positron emission tomography image fusion for conformal radiotherapy in esophageal carcinoma [J].

Moureau-Zabotto, L ;

Touboul, E ;

Lerouge, D ;

Deniaud-Alexandre, E ;

Grahek, D ;

Foulquier, JN ;

Petegnief, Y ;

Grès, B ;

El Balaa, H ;

Kerrou, K ;

Montravers, F ;

Keraudy, K ;

Tiret, E ;

Gendre, JP ;

Grange, JD ;

Houry, S ;

Talbot, JN .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 63 (02) :340-345

← 1 2 →