The ATP switch model for ABC transporters

被引：602

作者：

Higgins, CF ^{[1
]}

Linton, KJ ^{[1
]}

机构：

[1] MRC, Ctr Clin Sci, London W12 0NN, England

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nsmb836

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ABC transporters mediate active translocation of a diverse range of molecules across all cell membranes. They comprise two nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs). Recent biochemical, structural and genetic studies have led to the ATP-switch model in which ATP binding and ATP hydrolysis, respectively, induce formation and dissociation of an NBD dimer. This provides an exquisitely regulated switch that induces conformational changes in the TMDs to mediate membrane transport.

引用

收藏

页码：918 / 926

页数：9

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