Palladium(II)/N-Heterocyclic Carbene-Catalyzed Direct C-H Acylation of Heteroarenes with N-Acylsaccharins

被引：41

作者：

Karthik, Shanmugam ^{[1
]}

Gandhi, Thirumanavelan ^{[1
]}

机构：

[1] VIT Univ, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 19期

关键词：

AMIDES; FUNCTIONALIZATION; CLEAVAGE; PD; BENZOTHIAZOLE; BENZOXAZOLE; ACTIVATION; OXAZOLES; THIAZOLES; KETONES;

D O I：

10.1021/acs.orglett.7b02877

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Acylsaccharin represents a facile acyl group transfer agent to heteroarenes in the presence of Pd(II)/NHC complexes appended with a pyrene unit. Catalytic acylation of heteroarenes was enhanced by the noncovalent interaction between the pyrene unit and substrates. High functional group tolerance, broad substrate scope, and moderate to good yields of 2-acylated azoles are added features of this method.

引用

页码：5486 / 5489

页数：4

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