HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density

被引：0

作者：

Guerri-Fernandez, Robert ^{[1
,2
]}

Molina, Daniel ^{[2
,3
]}

Villar-Garcia, Judit ^{[1
,2
]}

Prieto-Alhambra, Daniel ^{[4
]}

Mellibovsky, Leonardo ^{[3
]}

Nogues, Xavier ^{[3
]}

Gonzalez-Mena, Alicia ^{[1
]}

Guelar, Ana ^{[1
]}

Trenchs-Rodriguez, Marta ^{[5
]}

Herrera-Fernandez, Sabina ^{[1
]}

Pablo Horcajada, Juan ^{[1
]}

Diez-Perez, Adolfo ^{[1
,3
]}

Knobel, Hernando ^{[1
]}

机构：

[1] Hosp del Mar, Res Inst IMIM, Dept Infect Dis, Barcelona, Spain

[2] Autonomous Univ Barcelona, Dept Med, Barcelona, Spain

[3] Hosp del Mar, Res Inst, Dept Internal Med, Barcelona, Spain

[4] Univ Oxford, Oxford NIHR Musculoskeletal Biomed Res Unit, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England

[5] Catalan Inst Hlth ICS, ABS Passeig St Joan, Primary Care, Barcelona, Spain

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 03期

关键词：

HIV; bone material properties; BMD; microindentation; IN-VIVO MEASUREMENT; RHEUMATOID-ARTHRITIS; FRACTURE RISK; MICROINDENTATION; METAANALYSIS; DISEASE; HEALTH; SEX; MEN;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.

引用

页码：314 / 318

页数：5

共 25 条

[1] Association of Hip Strength Estimates by Finite-Element Analysis With Fractures in Women and Men [J].

Amin, Shreyasee ;

Kopperdhal, David L. ;

Melton, L. Joseph, III ;

Achenbach, Sara J. ;

Therneau, Terry M. ;

Riggs, B. Lawrence ;

Keaveny, Tony M. ;

Khosla, Sundeep .

JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (07) :1593-1600

[2] Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents [J].

Bedimo, Roger ;

Maalouf, Naim M. ;

Zhang, Song ;

Drechsler, Henning ;

Tebas, Pablo .

AIDS, 2012, 26 (07) :825-831

[3] Low body weight mediates the relationship between HIV infection and low bone mineral density: A meta-analysis [J].

Bolland, Mark J. ;

Grey, Andrew B. ;

Gamble, Greg D. ;

Reid, Ian R. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (12) :4522-4528

[4] Reduced bone mineral density in human immunodeficiency virus-infected patients and its association with increased central adiposity and postload hyperglycemia [J].

Brown, TT ;

Ruppe, MD ;

Kassner, R ;

Kumar, P ;

Kehoe, T ;

Dobs, AS ;

Timpone, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (03) :1200-1206

[5] Mechanisms of disease: Cytokine pathways and joint inflammation in rheumatoid arthritis. [J].

Choy, EHS ;

Panayi, GS .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (12) :907-916

[6] Clinical use of bone densitometry - Scientific review [J].

Cummings, SR ;

Bates, D ;

Black, DM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (15) :1889-1897

[7] Microindentation for In Vivo Measurement of Bone Tissue Mechanical Properties in Humans [J].

Diez-Perez, Adolfo ;

Guerri, Roberto ;

Nogues, Xavier ;

Caceres, Enric ;

Jesus Pena, Maria ;

Mellibovsky, Leonardo ;

Randall, Connor ;

Bridges, Daniel ;

Weaver, James C. ;

Proctor, Alexander ;

Brimer, Davis ;

Koester, Kurt J. ;

Ritchie, Robert O. ;

Hansma, Paul K. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2010, 25 (08) :1877-1885

[8] In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes [J].

Farr, Joshua N. ;

Drake, Matthew T. ;

Amin, Shreyasee ;

Melton, L. Joseph, III ;

McCready, Louise K. ;

Khosla, Sundeep .

JOURNAL OF BONE AND MINERAL RESEARCH, 2014, 29 (04) :787-795

[9] Low Bone Mineral Density, Regardless of HIV Status, in Men Who Have Sex With Men [J].

Grijsen, Marlous L. ;

Vrouenraets, Saskia M. E. ;

Wit, Ferdinand W. N. M. ;

Stolte, Ineke G. ;

Prins, Maria ;

Lips, Paul ;

Reiss, Peter ;

Prins, Jan M. .

JOURNAL OF INFECTIOUS DISEASES, 2013, 207 (03) :386-391

[10] Continuous antiretroviral therapy decreases bone mineral density [J].

Grund, Birgit ;

Peng, Grace ;

Gibert, Cynthia L. ;

Hoy, Jennifer F. ;

Isaksson, Rachel L. ;

Shlay, Judith C. ;

Martinez, Esteban ;

Reiss, Peter ;

Visnegarwala, Fehmida ;

Carr, Andrew D. .

AIDS, 2009, 23 (12) :1519-1529

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