Mathematical model of controlled release of solute drugs from biodegradable implants

In medical sciences, chronical diseases and pathological states require long term doses of tablets, pills, capsules or ointments, creams, aerosols and injectables. These drugs release promptly but with significant fluctuations within various regions of the body. In this communication, we present a simple model for an alternative method Of drug release through erodible polymeric/ ceramic implants of desired geometry which can release the drug at a pre-assigned rate assuring effectiveness at lower end and minimizing adverse effect at the higher end. Such implants need not be removed after drug supply to the site by operating again because the implants are erodible. The model presents a control problem for design parameters for a pre-assigned drug release rate. The effects of various geometric and design parameters have been discussed.