The Association of Alanine Transaminase With Aging, Frailty, and Mortality

被引：139

作者：

Le Couteur, David G. ^{[1
,2
]}

Blyth, Fiona M. ^{[1
,3
,4
]}

Creasey, Helen M. ^{[1
]}

Handelsman, David J. ^{[2
]}

Naganathan, Vasi ^{[1
]}

Sambrook, Philip N. ^{[5
]}

Seibel, Markus J. ^{[2
]}

Waite, Louise M. ^{[1
]}

Cumming, Robert G. ^{[1
,2
,3
]}

机构：

[1] Univ Sydney, Concord RG Hosp, Ctr Educ & Res Ageing, Concord, NSW 2139, Australia

[2] Univ Sydney, Concord RG Hosp, ANZAC Res Inst, Concord, NSW 2139, Australia

[3] Univ Sydney, Sch Publ Hlth, Concord, NSW 2139, Australia

[4] Univ Sydney, Royal N Shore Hosp, Pain Management Res Inst, Concord, NSW 2139, Australia

[5] Univ Sydney, Royal N Shore Hosp, Inst Bone & Joint Res, Concord, NSW 2139, Australia

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2010年 / 65卷 / 07期

基金：

英国医学研究理事会;

关键词：

Alanine transaminase; Aging; Biomarker of aging; Frailty; Liver; Mortality; OLDER PERSONS; SERUM-ALBUMIN; AMINOTRANSFERASE ACTIVITY; TOTAL CHOLESTEROL; OBESITY; BIOMARKERS; AGE; INFLAMMATION; DISABILITY; DECLINE;

D O I：

10.1093/gerona/glq082

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The relationships between blood tests of liver function and injury (alanine transaminase [ALT], gamma-glutamyl transferase, bilirubin, and albumin) with age, frailty, and survival were investigated in 1,673 community-dwelling men aged 70 years or older. ALT was lower in older participants. Those participants with ALT below the median at baseline had reduced survival (hazard ratio 2.10, 95% confidence interval [CI] 1.53-2.87) up to 4.9 years. Older age, frailty, low albumin, low body mass index, and alcohol abstinence also were associated with reduced survival, with age and frailty being the most powerful predictors. Low ALT was associated with frailty (odds ratio 3.54, 95% CI 2.45-5.11), and the relationship between ALT and survival disappeared once frailty and age were included in the survival analysis. Low ALT activity is a predictor of reduced survival; however, this seems to be mediated by its association with frailty and increasing age. ALT has potential value as a novel biomarker of aging.

引用

页码：712 / 717

页数：6

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