The role of short course of high-dose methylprednisolone in children with acute myeloblastic leukemia (FAB M2) presented with myeloid tumor

被引：9

作者：

Hiçsönmez, G ^{[1
]}

Çetin, M ^{[1
]}

Aslan, D ^{[1
]}

Özyürek, E ^{[1
]}

机构：

[1] Hacettepe Univ, Ihsan Dogramaci Childrens Hosp, Dept Pediat Hematol, TR-06100 Ankara, Turkey

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2003年 / 20卷 / 05期

关键词：

acute myeloblastic leukemia; children; high-dose methylprednisolone; myeloid tumor;

D O I：

10.1080/08880010390203954

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The authors have previously demonstrated a favorable effect of high-dose methylprednisolone (HDMP), which can induce differentiation and apoptosis of leukemic cells in children with acute myeloblastic leukemia (AML). Here, they evaluate the effect of short-course HDMP in 2 children with acute myeloblastic leukemia (AML-M2) presented with myeloid tumor (MT). Methylprednisolone (20 or 30 mg/kg/day) was given orally, in a single dose, without using other antileukemic agents. Rapid cytoreduction in MT, peripheral blood, and bone marrow blasts was observed in both children following short-course (4 or 7 days) HDMP treatment, possibly due to HDMP-induced differentiation and apoptosis of leukemic cells. The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.

引用

页码：373 / 379

页数：7

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