The role of short course of high-dose methylprednisolone in children with acute myeloblastic leukemia (FAB M2) presented with myeloid tumor

被引：9
作者：
Hiçsönmez, G [1 ]
Çetin, M [1 ]
Aslan, D [1 ]
Özyürek, E [1 ]
机构：
[1] Hacettepe Univ, Ihsan Dogramaci Childrens Hosp, Dept Pediat Hematol, TR-06100 Ankara, Turkey
来源：
PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2003年 / 20卷 / 05期
关键词：
acute myeloblastic leukemia; children; high-dose methylprednisolone; myeloid tumor;
D O I：
10.1080/08880010390203954
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The authors have previously demonstrated a favorable effect of high-dose methylprednisolone (HDMP), which can induce differentiation and apoptosis of leukemic cells in children with acute myeloblastic leukemia (AML). Here, they evaluate the effect of short-course HDMP in 2 children with acute myeloblastic leukemia (AML-M2) presented with myeloid tumor (MT). Methylprednisolone (20 or 30 mg/kg/day) was given orally, in a single dose, without using other antileukemic agents. Rapid cytoreduction in MT, peripheral blood, and bone marrow blasts was observed in both children following short-course (4 or 7 days) HDMP treatment, possibly due to HDMP-induced differentiation and apoptosis of leukemic cells. The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.
引用
收藏
页码：373 / 379
页数：7
相关论文
共 35 条
[1]   Expression of the neural cell adhesion molecule CD56 is associated with short remission duration and survival in acute myeloid leukemia with t(8;21)(q22;q22) [J].
Baer, MR ;
Stewart, CC ;
Lawrence, D ;
Arthur, DC ;
Byrd, JC ;
Davey, FR ;
Schiffer, CA ;
Bloomfield, CD .
BLOOD, 1997, 90 (04) :1643-1648
[2]   Extramedullary infiltrates at diagnosis have no prognostic significance in children with acute myeloid leukaemia [J].
Bisschop, MM ;
Révész, T ;
Bierings, M ;
van Weerden, JF ;
van Wering, ER ;
Hählen, K ;
van der Does-van den Berg, A .
LEUKEMIA, 2001, 15 (01) :46-49
[3]   MODE OF CELL-DEATH INDUCED IN HUMAN LYMPHOID-CELLS BY HIGH AND LOW-DOSES OF GLUCOCORTICOID [J].
BLEWITT, RW ;
ABBOTT, AC ;
BIRD, CC .
BRITISH JOURNAL OF CANCER, 1983, 47 (04) :477-486
[4]  
CAVDAR AO, 1989, ACTA HAEMATOL-BASEL, V81, P80
[5]   Prognostic factors in children and adolescents with acute myeloid leukemia (excluding children with Down syndrome and acute promyelocytic leukemia): univariate and recursive partitioning analysis of patients treated on Pediatric Oncology Group (POC) Study 8821 [J].
Chang, M ;
Raimondi, SC ;
Ravindranath, Y ;
Carroll, AJ ;
Camitta, B ;
Gresik, MV ;
Steuber, CP ;
Weinstein, H .
LEUKEMIA, 2000, 14 (07) :1201-1207
[6]  
FRAPPAZ D, 1988, AM J PEDIAT HEMATOL, V10, P134
[7]   Dramatic resolution of pleural effusion in children with chronic myelomonocytic leukemia following short-course high-dose methylprednisolone [J].
Hiçsönmez, G ;
Çetin, M ;
Tunç, B ;
Tuncer, AM ;
Gümrük, F ;
Yenicesu, I .
LEUKEMIA & LYMPHOMA, 1998, 29 (5-6) :617-+
[8]   Differentiation of leukemic cells induced by short-course high-dose methylprednisolone in children with different subtypes of acute myeloblastic leukemia [J].
Hiçsönmez, G ;
Tuncer, M ;
Toksoy, HB ;
Yenicesu, I ;
Çetin, M .
LEUKEMIA & LYMPHOMA, 1999, 33 (5-6) :573-+
[9]   The potential effect of short-course high-dose steroid on the maturation and apoptosis of leukemic cells in a child with acute megakaryoblastic leukemia [J].
Hiçsönmez, G ;
Çetin, M ;
Okur, H ;
Erdemli, E ;
Gürgey, A .
LEUKEMIA & LYMPHOMA, 2003, 44 (06) :1037-1042
[10]   Evaluation of children with myelodysplastic syndrome:: Importance of extramedullary disease as a presenting symptom [J].
Hiçsönmez, G ;
Çetin, M ;
Yenicesu, I ;
Olcay, L ;
Koç, A ;
Aktas, D ;
Tunçbilek, E ;
Tuncer, KM .
LEUKEMIA & LYMPHOMA, 2001, 42 (04) :665-674
1234