PD-1+ T cells:: exhausted and premature?

被引：1
|
作者：
Su, Lishan [1 ]
机构：
[1] Univ N Carolina, Chapel Hill, NC 27599 USA
来源：
BLOOD | 2007年 / 109卷 / 11期
关键词：
D O I：
10.1182/blood-2007-03-079434
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
PD-1 up-regulation is correlated with the exhaustion of virus-specific CD8 T cells in people chronically infected with HIV-1. Zhang and colleagues report that PD-1 is up-regulated on HIV-specific CD8 T cells in typical disease progressors (TPs) but not in long-term nonprogressor (LTNP) patients, and PDA expression is down-regulated in HIV-1 patients with successful response to HAART therapy.
引用
收藏
页码：4593 / 4594
页数：2
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