The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells

被引：40
作者：
Torres-Flores, Jesus M. [1 ]
Silva-Ayala, Daniela [1 ]
Espinoza, Marco A. [1 ]
Lopez, Susana [1 ]
Arias, Carlos F. [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Biotechnol, Cuernavaca 62210, Morelos, Mexico
来源：
VIROLOGY | 2015年 / 475卷
关键词：
Rotavirus; Virus entry; Tight junction proteins; JAM-A; Occludin; ZO-1; ADHESION MOLECULE; EARLY STEPS; OCCLUDIN; INFECTION; RECEPTOR; ZO-1; REOVIRUS; COMPLEX; ENTER; REPLICATION;
D O I：
10.1016/j.virol.2014.11.016
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Several molecules have been identified as receptors or coreceptors for rotavirus infection, including glycans, integrins, and hsc70. In this work we report that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells. JAM-A was found to function as coreceptor for rotavirus strains RRV, Wa, and UK, but not for rotavirus YM. Reassortant viruses derived from rotaviruses RRV and YM showed that the virus spike protein VP4 determines the use of JAM-A as coreceptor. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：172 / 178
页数：7
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