Potential roles of N6-methyladenosine (m6A) in immune cells

被引：56

作者：

Liu, Chang ^{[1
]}

Yang, Zhe ^{[2
]}

Li, Rong ^{[2
]}

Wu, Yanju ^{[3
]}

Chi, Ming ^{[3
]}

Gao, Shuting ^{[3
]}

Sun, Xun ^{[4
]}

Meng, Xin ^{[3
]}

Wang, Biao ^{[3
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, 155 NanJing North Rd, Shenyang, Peoples R China

[2] Liaoning Univ, Coll Life Sci, 66 Chongshan Rd, Shenyang 110036, Peoples R China

[3] China Med Univ, Sch Life Sci, Dept Biochem & Mol Biol, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China

[4] China Med Univ, Coll Basic Med Sci, Dept Immunol, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2021年 / 19卷 / 01期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

N6-methyladenosine; Immune cells; RNAs; M(6)A RNA METHYLATION; HEMATOPOIETIC STEM-CELL; MESSENGER-RNA; DEMETHYLASE ALKBH5; NUCLEAR-RNA; MICRORNAS; PROTEIN; METTL3; DIFFERENTIATION; TUMORIGENICITY;

D O I：

10.1186/s12967-021-02918-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human diseases. Therefore, m6A modification has become a research hotspot for its potential therapeutic applications in the treatment of various diseases. The immune system mostly involves different types of immune cells to provide the first line of defense against infections. The immunoregulatory network that orchestrate the immune responses to new pathogens plays a pivotal role in the development of the disease. And m6A modification has been demonstrated to be a major post-transcriptional regulator of immune responses in cells. In this review, we summarize the participants involved in m6A regulation and try to reveal how m6A modification affects the immune responses via changing the immunoregulatory networks.

引用

页数：13

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