Smart and eco-friendly N-isopropylacrylamide and cellulose hydrogels as a safe dual-drug local cancer therapy approach

被引：24

作者：

Andrade, Fernanda ^{[1
,2
,3
]}

Roca-Melendres, Maria Merce ^{[1
,2
]}

Llaguno, Monserrat ^{[1
,2
]}

Hide, Diana ^{[4
,5
]}

Raurell, Imma ^{[4
,5
]}

Martell, Maria ^{[4
,5
]}

Vijayakumar, Sekar ^{[6
]}

Oliva, Mireia ^{[2
,3
,7
]}

Schwartz, Simo, Jr. ^{[1
,8
]}

Duran-Lara, Esteban F. ^{[9
,10
]}

Rafael, Diana ^{[1
,2
]}

Abasolo, Ibane ^{[1
,2
,11
]}

机构：

[1] Univ Autonoma Barcelona UAB, Vall Hebron Inst Recerca VHIR, Drug Delivery & Targeting, Barcelona 08035, Spain

[2] Inst Salud Carlos III, Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Madrid 28029, Spain

[3] Univ Barcelona UB, Fac Pharm & Food Sci, Sch Pharm, Dept Pharm & Pharmaceut Technol & Physicochem, Barcelona 08028, Spain

[4] Univ Autonoma Barcelona UAB, Hosp Univ Vall Hebron, Vall Hebron Inst Recerca VHIR, Dept Med,Liver Unit, Barcelona 08035, Spain

[5] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain

[6] Shandong Univ, Marine Coll, Weihai 264209, Peoples R China

[7] Inst Bioengn Catalonia IBEC, Nanoprobes & Nanoswitches, Barcelona 08028, Spain

[8] Hosp Univ Vall Hebron, Serv Bioquim, Barcelona 08035, Spain

[9] Univ Talca, Bio & Nanomat Lab, Drug Delivery & Controlled Release, POB 747, Talca 1141, Maule, Chile

[10] Univ Talca, Fac Ciencias Salud, Dept Microbiol, POB 747, Talca 1141, Maule, Chile

[11] Univ Autonoma Barcelona UAB, Vall Hebron Inst Recerca VHIR, Funct Validat & Preclin Res FVPR, U20 ICTS Nanbiosis, Barcelona 08035, Spain

来源：

CARBOHYDRATE POLYMERS | 2022年 / 295卷

关键词：

Biodegradable; cancer treatment; Cellulose; Controlled-release formulation; Drug delivery systems; Hydrogel; Thermo-responsiveness; AMMONIUM-NITRATE; DELIVERY; REDUCE;

D O I：

10.1016/j.carbpol.2022.119859

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Local cancer treatment by in situ injections of thermo-responsive hydrogels (HG) offers several advantages over conventional systemic anti-cancer treatments. In this work, a biodegradable and multicompartmental HG composed of N-isopropylacrylamide, cellulose, citric acid, and ceric ammonium nitrate was developed for the controlled release of hydrophilic (doxorubicin) and hydrophobic (niclosamide) drugs. The formulation presented ideal properties regarding thermo-responsiveness, rheological behavior, drug release profile, biocompatibility, and biological activity in colon and ovarian cancer cells. Cellulose was found to retard drugs release rate, being only 4 % of doxorubicin and 30 % of niclosamide released after 1 week. This low release was sufficient to cause cell death in both cell lines. Moreover, HG demonstrated a proper injectability, in situ prevalence, and safety profile in vivo. Overall, the HG properties, together with its natural and eco-friendly composition, create a safe and efficient platform for the local treatment of non-resectable tumors or tumors requiring pre-surgical adjuvant therapy.

引用

页数：15

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