Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted?

被引：20

作者：

Weiner, Louis M. ^{[1
]}

Surana, Rishi ^{[1
]}

Murray, Joseph ^{[1
]}

机构：

[1] Georgetown Univ, Georgetown Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA

来源：

CANCER PREVENTION RESEARCH | 2010年 / 3卷 / 04期

关键词：

FIBROBLAST ACTIVATION PROTEIN; REGULATORY T-CELLS; BREAST-CANCER; MOUSE MODEL; TUMOR; CYCLOOXYGENASE-2; IMMUNOTHERAPY; LYMPHOCYTES; EXPRESSION; INHIBITOR;

D O I：

10.1158/1940-6207.CAPR-10-0040

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This perspective on the report by Beatty et al. in this issue of the journal (beginning on page 438) discusses the prevention of cancer through vaccination strategies that target antigens associated with tumor promotion and progression. Such approaches were first developed for treating cancer. We address cancer vaccination in the context of a mouse model of inflammatory bowel disease expressing MUC1, an epithelial mucin aberrantly expressed during chronic inflammation and in colorectal carcinogenesis, and in a broader context that includes the potential of targeting the tumor microenvironment for immunoprevention in humans. Obstacles in developing effective cancer vaccines, including antigen selection, immunoediting, and tumor-mediated immunosuppression, are also discussed. Cancer Prev Res; 3(4); 410-5. (C)2010 AACR.

引用

页码：410 / 415

页数：6

共 45 条

[11] UP-REGULATION OF CYCLOOXYGENASE-2 GENE-EXPRESSION IN HUMAN COLORECTAL ADENOMAS AND ADENOCARCINOMAS [J].

EBERHART, CE ;

COFFEY, RJ ;

RADHIKA, A ;

GIARDIELLO, FM ;

FERRENBACH, S ;

DUBOIS, RN .

GASTROENTEROLOGY, 1994, 107 (04) :1183-1188

[12] Hepatocellular carcinoma in cirrhosis: Incidence and risk factors [J].

Fattovich, G ;

Stroffolini, T ;

Zagni, I ;

Donato, F .

GASTROENTEROLOGY, 2004, 127 (05) :S35-S50

[13] Lessons from randomized phase III studies with active cancer immunotherapies - Outcomes from the 2006 Meeting of the Cancer Vaccine Consortium (CVC) [J].

Finke, Lothar H. ;

Wentworth, Kerry ;

Blumenstein, Brent ;

Rudolph, Natalie S. ;

Levitsky, Hyarn ;

Hoos, Axel .

VACCINE, 2007, 25 :B97-B109

[14] Integrative Discovery of Epigenetically Derepressed Cancer Testis Antigens in NSCLC [J].

Glazer, Chad A. ;

Smith, Ian M. ;

Ochs, Michael F. ;

Begum, Shahnaz ;

Westra, William ;

Chang, Steven S. ;

Sun, Wenyue ;

Bhan, Sheetal ;

Khan, Zubair ;

Ahrendt, Steven ;

Califano, Joseph A. .

PLOS ONE, 2009, 4 (12)

[15] Immunophenotypic characterization of 225 prostate adenocarcinomas with intermediate or high Gleason scores [J].

Goldstein, NS .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2002, 117 (03) :471-477

[16] Level of HER-2/neu protein expression in breast cancer may affect the development of endogenous HER-2/neu-specific immunity [J].

Goodell, Vivian ;

Waisman, James ;

Salazar, Lupe G. ;

dela Rosa, Corazon ;

Link, John ;

Coveler, Andrew L. ;

Childs, Jennifer S. ;

Fintak, Patricia A. ;

Higgins, Doreen M. ;

Disis, Mary L. .

MOLECULAR CANCER THERAPEUTICS, 2008, 7 (03) :449-454

[17]

Haigh PI, 1999, ONCOLOGY-NY, V13, P1561

[18] The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors [J].

Hedvat, Michael ;

Huszar, Dennis ;

Herrmann, Andreas ;

Gozgit, Joseph M. ;

Schroeder, Anne ;

Sheehy, Adam ;

Buettner, Ralf ;

Proia, David ;

Kowolik, Claudia M. ;

Xin, Hong ;

Armstrong, Brian ;

Bebernitz, Geraldine ;

Weng, Shaobu ;

Wang, Lin ;

Ye, Minwei ;

McEachern, Kristen ;

Chen, Huawei ;

Morosini, Deborah ;

Bell, Kirsten ;

Alimzhanov, Marat ;

Ioannidis, Stephanos ;

McCoon, Patricia ;

Cao, Zhu A. ;

Yu, Hua ;

Jove, Richard ;

Zinda, Michael .

CANCER CELL, 2009, 16 (06) :487-497

[19] Integrated Data From 2 Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trials of Active Cellular Immunotherapy With Sipuleucel-T in Advanced Prostate Cancer [J].

Higano, Celestia S. ;

Schellhammer, Paul F. ;

Small, Eric J. ;

Burch, Patrick A. ;

Nemunaitis, John ;

Yuh, Lianng ;

Provost, Nicole ;

Frohlich, Mark W. .

CANCER, 2009, 115 (16) :3670-3679

[20] Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis [J].

Hull, MA ;

Faluyi, OO ;

Ko, CWS ;

Holwell, S ;

Scott, DJ ;

Cuthbert, RJ ;

Poulsom, R ;

Goodlad, R ;

Bonifer, C ;

Markham, AF ;

Coletta, PL .

CARCINOGENESIS, 2006, 27 (03) :382-391

← 1 2 3 4 5 →