Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted?

被引：20

作者：

Weiner, Louis M. ^{[1
]}

Surana, Rishi ^{[1
]}

Murray, Joseph ^{[1
]}

机构：

[1] Georgetown Univ, Georgetown Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA

来源：

CANCER PREVENTION RESEARCH | 2010年 / 3卷 / 04期

关键词：

FIBROBLAST ACTIVATION PROTEIN; REGULATORY T-CELLS; BREAST-CANCER; MOUSE MODEL; TUMOR; CYCLOOXYGENASE-2; IMMUNOTHERAPY; LYMPHOCYTES; EXPRESSION; INHIBITOR;

D O I：

10.1158/1940-6207.CAPR-10-0040

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This perspective on the report by Beatty et al. in this issue of the journal (beginning on page 438) discusses the prevention of cancer through vaccination strategies that target antigens associated with tumor promotion and progression. Such approaches were first developed for treating cancer. We address cancer vaccination in the context of a mouse model of inflammatory bowel disease expressing MUC1, an epithelial mucin aberrantly expressed during chronic inflammation and in colorectal carcinogenesis, and in a broader context that includes the potential of targeting the tumor microenvironment for immunoprevention in humans. Obstacles in developing effective cancer vaccines, including antigen selection, immunoediting, and tumor-mediated immunosuppression, are also discussed. Cancer Prev Res; 3(4); 410-5. (C)2010 AACR.

引用

页码：410 / 415

页数：6

共 45 条

[1] Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas [J].

Akporiaye, Emmanuel T. ;

Bradley-Dunlop, Deborah ;

Gendler, Sandra J. ;

Mukherjee, Pinku ;

Madsen, Cathy S. ;

Hahn, Tobias ;

Besselsen, David G. ;

Dial, Sharon M. ;

Cui, Haiyan ;

Trevor, Katrina .

VACCINE, 2007, 25 (39-40) :6965-6974

[2] Celecoxib for the prevention of colorectal adenomatous polyps [J].

Arber, Nadir ;

Eagle, Craig J. ;

Spicak, Julius ;

Racz, Istvan ;

Dite, Petr ;

Hajer, Jan ;

Zavoral, Miroslav ;

Lechuga, Maria J. ;

Gerletti, Paola ;

Tang, Jie ;

Rosenstein, Rebecca B. ;

Macdonald, Katie ;

Bhadra, Pritha ;

Fowler, Robert ;

Wittes, Janet ;

Zauber, Ann G. ;

Solomon, Scott D. ;

Levin, Bernard .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) :885-895

[3] Vaccine against MUC1 Antigen Expressed in Inflammatory Bowel Disease and Cancer Lessens Colonic Inflammation and Prevents Progression to Colitis-Associated Colon Cancer [J].

Beatty, Pamela L. ;

Narayanan, Sowmya ;

Gariepy, Jean ;

Ranganathan, Sarangarajan ;

Finn, Olivera J. .

CANCER PREVENTION RESEARCH, 2010, 3 (04) :438-446

[4] A NEW ANTIGEN IN LEUKEMIA SERA [J].

BLUMBERG, BS ;

ALTER, HJ ;

VISNICH, S .

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1965, 191 (07) :541-&

[5] CANCER - A BIOLOGICAL APPROACH .1. THE PROCESSES OF CONTROL [J].

BURNET, M .

BRITISH MEDICAL JOURNAL, 1957, 1 (APR6) :779-786

[6] The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research [J].

Cheever, Martin A. ;

Allison, James P. ;

Ferris, Andrea S. ;

Finn, Olivera J. ;

Hastings, Benjamin M. ;

Hecht, Toby T. ;

Mellman, Ira ;

Prindiville, Sheila A. ;

Viner, Jaye L. ;

Weiner, Louis M. ;

Matrisian, Lynn M. .

CLINICAL CANCER RESEARCH, 2009, 15 (17) :5323-5337

[7]

Cheng JD, 2005, MOL CANCER THER, V4, P351

[8] Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival [J].

Curiel, TJ ;

Coukos, G ;

Zou, LH ;

Alvarez, X ;

Cheng, P ;

Mottram, P ;

Evdemon-Hogan, M ;

Conejo-Garcia, JR ;

Zhang, L ;

Burow, M ;

Zhu, Y ;

Wei, S ;

Kryczek, I ;

Daniel, B ;

Gordon, A ;

Myers, L ;

Lackner, A ;

Disis, ML ;

Knutson, KL ;

Chen, LP ;

Zou, WP .

NATURE MEDICINE, 2004, 10 (09) :942-949

[9] Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer [J].

Doherty, G. A. ;

Byrne, S. M. ;

Austin, S. C. ;

Scully, G. M. ;

Sadlier, D. M. ;

Neilan, T. G. ;

Kay, E. W. ;

Murray, F. E. ;

Fitzgerald, D. J. .

BRITISH JOURNAL OF CANCER, 2009, 101 (03) :483-491

[10] Cancer immunoediting: from immunosurveillance to tumor escape [J].

Dunn, GP ;

Bruce, AT ;

Ikeda, H ;

Old, LJ ;

Schreiber, RD .

NATURE IMMUNOLOGY, 2002, 3 (11) :991-998

← 1 2 3 4 5 →