Extension of life-span with superoxide dismutase/catalase mimetics

被引:708
作者
Melov, S
Ravenscroft, J
Malik, S
Gill, MS
Walker, DW
Clayton, PE
Wallace, DC
Malfroy, B
Doctrow, SR
Lithgow, GJ [1 ]
机构
[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
[2] Univ Manchester, Acad Unit Child Hlth, Manchester M13 9PT, Lancs, England
[3] Buck Inst Age Res, Novato, CA 94949 USA
[4] Eukarion, Bedford, MA 01730 USA
[5] Emory Univ, Ctr Mol Med, Atlanta, GA 30322 USA
关键词
D O I
10.1126/science.289.5484.1567
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean Life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of Life-span and that it can be counteracted by pharmacological intervention.
引用
收藏
页码:1567 / 1569
页数:3
相关论文
共 21 条
[1]  
Baker K, 1998, J PHARMACOL EXP THER, V284, P215
[2]   AGING, ENERGY, AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES [J].
BEAL, MF .
ANNALS OF NEUROLOGY, 1995, 38 (03) :357-366
[3]  
Beckman K.B., 1997, OXIDATIVE STRESS MOL, P201
[4]   beta-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger [J].
Bruce, AJ ;
Malfroy, B ;
Baudry, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2312-2316
[5]  
Doctrow S R, 1997, Adv Pharmacol, V38, P247
[6]   EFFECT OF VITAMIN-E ON LIFESPAN AND REPRODUCTION IN CAENORHABDITIS-ELEGANS [J].
HARRINGTON, LA ;
HARLEY, CB .
MECHANISMS OF AGEING AND DEVELOPMENT, 1988, 43 (01) :71-78
[7]   A METHYL VIOLOGEN-SENSITIVE MUTANT OF THE NEMATODE CAENORHABDITIS-ELEGANS [J].
ISHII, N ;
TAKAHASHI, K ;
TOMITA, S ;
KEINO, T ;
HONDA, S ;
YOSHINO, K ;
SUZUKI, K .
MUTATION RESEARCH, 1990, 237 (3-4) :165-171
[8]   A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes [J].
Ishii, N ;
Fujii, M ;
Hartman, PS ;
Tsuda, M ;
Yasuda, K ;
Senoo-Matsuda, N ;
Yanase, S ;
Ayusawa, D ;
Suzuki, K .
NATURE, 1998, 394 (6694) :694-697
[9]   INCREASED LIFE-SPAN OF AGE-1 MUTANTS IN CAENORHABDITIS-ELEGANS AND LOWER GOMPERTZ RATE OF AGING [J].
JOHNSON, TE .
SCIENCE, 1990, 249 (4971) :908-912
[10]   Determination of life-span in Caenorhabditis elegans by four clock genes [J].
Lakowski, B ;
Hekimi, S .
SCIENCE, 1996, 272 (5264) :1010-1013