Progressing actin: sFormin as a processive elongation machine

被引：39

作者：

Kovar, DR ^{[1
]}

Pollard, TD

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Yale Univ, Dept Cell Biol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 12期

关键词：

D O I：

10.1038/ncb1204-1158

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Formins are a family of structurally conserved proteins that regulate the assembly of the fast-growing end of actin filaments. New work shows that the molecular mechanism of formin function is conserved but that the rates of the reactions vary within and between species to such a degree that the mechanisms of various formin family members may seem to differ qualitatively.

引用

页码：1158 / 1159

页数：2

共 10 条

[1] Force generation by cytoskeletal filament end-tracking proteins [J].

Dickinson, RB ;

Caro, L ;

Purich, DL .

BIOPHYSICAL JOURNAL, 2004, 87 (04) :2838-2854

[2] The mouse formin, FRLα, slows actin filament barbed end elongation, competes with capping protein, accelerates polymerization from monomers, and severs filaments [J].

Harris, ES ;

Li, F ;

Higgs, HN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (19) :20076-20087

[3] Actin polymerization-driven molecular movement of mDia1 in living cells [J].

Higashida, C ;

Miyoshi, T ;

Fujita, A ;

OcegueraYanez, F ;

Monypenny, J ;

Andou, Y ;

Narumiya, S ;

Watanabe, N .

SCIENCE, 2004, 303 (5666) :2007-2010

[4] The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin [J].

Kovar, DR ;

Kuhn, JR ;

Tichy, AL ;

Pollard, TD .

JOURNAL OF CELL BIOLOGY, 2003, 161 (05) :875-887

[5] Insertional assembly of actin filament barbed ends in association with formins produces piconewton forces [J].

Kovar, DR ;

Pollard, TD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (41) :14725-14730

[6] Reconstitution of actin-based motility of Listeria and Shigella using pure proteins [J].

Loisel, TP ;

Boujemaa, R ;

Pantaloni, D ;

Carlier, MF .

NATURE, 1999, 401 (6753) :613-616

[7] A conserved mechanism for Bni1-and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin [J].

Moseley, JB ;

Sagot, I ;

Manning, AL ;

Xu, YW ;

Eck, J ;

Pellman, D ;

Goode, BL .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (02) :896-907

[8] Cellular motility driven by assembly and disassembly of actin filaments [J].

Pollard, TD ;

Borisy, GG .

CELL, 2003, 112 (04) :453-465

[9] Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis [J].

Romero, S ;

Le Clainche, C ;

Didry, D ;

Egile, C ;

Pantaloni, D ;

Carlier, MF .

CELL, 2004, 119 (03) :419-429

[10] Formin leaky cap allows elongation in the presence of tight capping proteins [J].

Zigmond, SH ;

Evangelista, M ;

Boone, C ;

Yang, CS ;

Dar, AC ;

Sicheri, F ;

Forkey, J ;

Pring, M .

CURRENT BIOLOGY, 2003, 13 (20) :1820-1823

← 1 →