Increasing demonstration of angiogenic markers in skin neoplastic lesions

被引：7

作者：

de Almeida, Carla Mendonca ^{[1
]}

de Jesus, Sabina Ferreira ^{[1
]}

Poswar, Fabiano de Oliveira ^{[1
,2
]}

Batista Gomes, Emisael Stenio ^{[1
]}

de Carvalho Frag, Carlos Alberto ^{[1
]}

Farias, Lucyana Conceicao ^{[1
]}

Souza Santos, Sergio Henrique ^{[3
]}

Feltenberger, John David ^{[4
]}

Batista de Paula, Alfredo Mauricio ^{[1
]}

Sena Guimaraes, Andre Luiz ^{[1
]}

机构：

[1] Univ Estadual Montes Claros, Dept Dent, Montes Claros, MG, Brazil

[2] Univ Estadual Montes Claros, Dept Med, Montes Claros, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Agr Sci, Montes Claros, MG, Brazil

[4] Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79409 USA

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2016年 / 212卷 / 02期

关键词：

Basal cell carcinoma; Squamous cell carcinoma; Actinic keratosis; Skin cancer; Membrane-type matrix metalloproteinase 1; Matrix metalloproteinase-2; BASAL-CELL CARCINOMA; CANCER; MELANOMA; PATHWAY;

D O I：

10.1016/j.prp.2015.12.004

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background: Skin cancer represents the most common worldwide malignancy. Angiogenesis is an important factor in tumor growth and metastasis. Given these facts, the purpose of the current study was to compare the levels of angiogenic proteins in the context of the most common malignant and premalignant skin lesions. Methods: Immunohistochemistry of CD31, HIF1A, VEGFR1 and VEGFR2 was performed in basal cell carcinoma (BCC), actinic keratosis (AK) and squamous cell carcinoma of the skin (SCCS). Results: SCCS presented with increased levels of HIF1A, VEGFR1 and VEGFR2 in comparison to AK. In addition, SCCS also demonstrated increased levels of HIF1A to BCCLR or BCCHR. BCC presented with more vessels than AK. However, no correlation was observed among CD31, HIF1A, VEGFR1 and VEGFR2. Conclusions: SCCS presented with higher levels of HIF1A, VEGFR1 and VEGFR2, while BCC demonstrated an increased number of vessels in relation to AK. These data suggest that antiangiogenic therapy might be useful for skin cancer treatment. (C) 2015 Elsevier GmbH. All rights reserved.

引用

页码：101 / 105

页数：5

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