Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue

被引:100
作者
Kocks, Jessica R. [1 ]
Davalos-Misslitz, Ana Clara Marques [1 ]
Hintzen, Gabriele [1 ]
Ohl, Lars [1 ]
Foerster, Reinhold [1 ]
机构
[1] Hannover Med Sch, Inst Immunol, D-30625 Hannover, Germany
关键词
D O I
10.1084/jem.20061424
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Presence and extent of bronchus-associated lymphoid tissue ( BALT) is subject to considerable variations between species and is only occasionally observed in lungs of mice. Here we demonstrate that mice deficient for the chemokine receptor CCR7 regularly develop highly organized BALT. These structures were not present at birth but were detectable from day 5 onwards. Analyzing CCR7(-/-)/wild-type bone marrow chimeras, we demonstrate that the development of BALT is caused by alterations of the hematopoietic system in CCR7-deficient mice. These observations together with the finding that CCR7-deficient mice posses dramatically reduced numbers of regulatory T cells ( T reg cells) in the lung-draining bronchial lymph node suggest that BALT formation might be caused by disabled in situ function of T reg cells. Indeed, although adoptive transfer of wild-type T reg cells to CCR7-deficient recipients resulted in a profound reduction of BALT formation, neither naive wild-type T cells nor T reg cells from CCR7(-/-) donors impair BALT generation. Furthermore, we provide evidence that CCR7-deficient T reg cells, although strongly impaired in homing to peripheral lymph nodes, are fully effective in vitro. Thus our data reveal a CCR7-dependent homing of T reg cells to peripheral lymph nodes in conjunction with a role for these cells in controlling BALT formation.
引用
收藏
页码:723 / 734
页数:12
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