Isolation and characterization of pathogenic Leishmania turanica from Nesokia indica (Rodentia, Muridae) by PCR-RFLP and ITS1 sequencing in Iran

被引：24

作者：

Hajjaran, H. ^{[1
,2
]}

Mohebali, M. ^{[1
,2
]}

Alimoradi, S. ^{[1
,2
]}

Abaei, M. R. ^{[3
,4
]}

Edrissian, Gh. H. ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Dept Med Parasitol & Mycol, Sch Publ Hlth, Tehran, Iran

[2] Univ Tehran Med Sci, Dept Med Parasitol & Mycol, Publ Hlth Res Inst, Tehran, Iran

[3] Univ Tehran Med Sci, Dept Med Entomol & Vector Control, Sch Publ Hlth, Tehran, Iran

[4] Univ Tehran Med Sci, Dept Med Entomol & Vector Control, Publ Hlth Res Inst, Tehran, Iran

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 103卷 / 11期

关键词：

Nesokia indica; Leishmania turanico; Pathogenicity; PCR-RFLP; Iran;

D O I：

10.1016/j.trstmh.2008.08.016

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Zoonotic cutaneous leishmaniasis, primarily an infection of desert rodents, is an important endemic disease in some parts of Iran. In spite of reporting Leishmania infection in Nesokia indica microscopically, its rote remains unclear in Iran. We report the first natural infection by Leishmania turanica in a wild-caught N. indica in the west part of Iran, near the border with Iraq. The evidence is in the form of PCR-RFLP testing based on internal transcribed spacer 1 (ITS1) rDNA with HaeIII enzyme and ITS1 sequence analysis. This isolate was highly pathogenic in BALB/c mice and golden hamsters and caused Lethal systemic infection in the former. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：1177 / 1179

页数：3

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