Metallothioneins: historical review and state of knowledge

被引：226
作者：
Nordberg, M [1 ]
机构：
[1] Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden
来源：
TALANTA | 1998年 / 46卷 / 02期
关键词：
metallothionein; protein; quantification; metals; metabolism; polymorphism; gender; disease;
D O I：
10.1016/S0039-9140(97)00345-7
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The history of metallothionein (MT) research is reviewed. Various methods for isolation, characterisation and quantification are evaluated. The role of MT in metal metabolism and toxicity is explained. Gender differences and polymorphisms are brought to the attention of the reader and the possible relationship with disease is discussed. The review is an evaluation based on data from literature and from own original experimental data. Future aspects on research within the MT field is stressed. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码：243 / 254
页数：12
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