The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss

被引：5

作者：

Kim, Byung-Jin ^{[1
]}

Zack, Donald J. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2018年 / 1074卷

关键词：

c-Jun N-terminal Kinase (JNK); Retinal degeneration; Retinal ganglion cell (RGC); Optic neuropathy; Retinal pigmented epithelial (RPE) cell; Age-related macular degeneration (AMD); Photoreceptor cells; Retinitis pigmentosa; Therapeutic target; ACTIVATED PROTEIN-KINASES; GANGLION-CELL DEATH; PIGMENT EPITHELIUM; MACULAR DEGENERATION; RETINITIS-PIGMENTOSA; INDUCED APOPTOSIS; ARPE19; CELLS; IN-VIVO; PATHWAY; INHIBITION;

D O I：

10.1007/978-3-319-75402-4_43

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

c-Jun N-terminal kinase (JNK), a member of stress-induced mitogen-activated protein (MAP) kinase family, has been shown to modulate a variety of biological processes associated with neurodegenerative pathology of the retina. In particular, various retinal cell culture and animal models related to glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa indicate that JNK signaling may contribute to disease pathogenesis. This mini-review discusses the impact of JNK signaling in retinal disease, with a focus on retinal ganglion cells (RGCs), photoreceptor cells, retinal pigment epithelial (RPE) cells, and animal studies, with particular attention to modulation of JNK signaling as a potential therapeutic target for the treatment of retinal disease.

引用

页码：351 / 357

页数：7

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