Role of glutathione S-transferase Mu-1 (GSTM1) polymorphism in oligospermic infertile males

被引：40

作者：

Vani, G. Tirumala ^{[1
]}

Mukesh, N. ^{[1
]}

Prasad, B. Siva ^{[1
]}

Devi, P. Rama ^{[2
]}

Prasad, M. Hema ^{[1
]}

Rani, P. Usha ^{[1
,3
]}

Reddy, P. Pardhanandana ^{[1
,3
]}

机构：

[1] Osmania Univ, Inst Genet & Hosp Genet Dis, Hyderabad 500007, Andhra Pradesh, India

[2] Mahatma Gandhi Natl Inst Res & Social Act, Ramas Inst Fertil, Hyderabad, Andhra Pradesh, India

[3] Mahatma Gandhi Natl Inst Res & Social Act, Sch Human Genome Res & Genet Disorders, Hyderabad, Andhra Pradesh, India

来源：

ANDROLOGIA | 2010年 / 42卷 / 04期

关键词：

GSTM1; polymorphism; male infertility; oligospermic; oxidative stress; NULL GENOTYPE; DAMAGE; CANCER; SPERM; RISK; M1;

D O I：

10.1111/j.1439-0272.2009.00971.x

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

P>The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Forty-two men with infertility and 43 fertile men were recruited for this study. GSTM1 gene was analysed using PCR technique. The frequency of GSTM1 null (-) genotype was observed to be 45.2% in infertile men as against 20.09% in fertile men. Subjects with the GSTM1 null genotype had lower sperm concentrations and motility when compared with the subjects with GSTM1-positive genotype in both the groups. This study shows that the frequency of GSTM1 null (-) genotype is significantly high in infertile males when compared with the frequency in fertile males (OR = 0.32, P = 0.017, 95% CI = 0.124-0.831).

引用

页码：213 / 217

页数：5

共 19 条

[1] Oxidative stress, DNA damage and the Y chromosome
Aitken, RJ
Krausz, C
[J]. REPRODUCTION, 2001, 122 (04) : 497 - 506
[2] Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype
Aydemir, Birsen
Onaran, Ilhan
Kiziler, Ali R.
Alici, Bulent
Akyolcu, Mehmet C.
[J]. ASIAN JOURNAL OF ANDROLOGY, 2007, 9 (01) : 108 - 115
[3] Babu SR, 2002, ASIAN J ANDROL, V4, P265
[4] GENETIC RISK AND CARCINOGEN EXPOSURE - A COMMON INHERITED DEFECT OF THE CARCINOGEN-METABOLISM GENE GLUTATHIONE-S-TRANSFERASE M1 (GSTM1) THAT INCREASES SUSCEPTIBILITY TO BLADDER-CANCER
BELL, DA
TAYLOR, JA
PAULSON, DF
ROBERTSON, CN
MOHLER, JL
LUCIER, GW
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (14) : 1159 - 1164
[5] GENETIC-HETEROGENEITY OF THE HUMAN GLUTATHIONE TRANSFERASES - A COMPLEX OF GENE FAMILIES
BOARD, P
COGGAN, M
JOHNSTON, P
ROSS, V
SUZUKI, T
WEBB, G
[J]. PHARMACOLOGY & THERAPEUTICS, 1990, 48 (03) : 357 - 369
[6] Castellón EA, 1999, INT J ANDROL, V22, P49
[7] Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele
Chen, SS
Chang, LS
Chen, HW
Wei, YH
[J]. HUMAN REPRODUCTION, 2002, 17 (03) : 718 - 725
[8] Geva E, 1998, HUM REPROD, V13, P1422
[9] Inhibition of sperm glutathione S-transferase leads to functional impairment due to membrane damage
Gopalakrishnan, B
Shaha, C
[J]. FEBS LETTERS, 1998, 422 (03) : 296 - 300
[10] HIDEYA K, 1997, FERTIL STERIL, V68, P519

← 1 2 →