Manipulation of D2 receptors with quinpirole and sulpiride affects locornotor activity before spatial behavior of rats in an active place avoidance task

Dopamine-mediated neurotransmission is widely studied with respect to motivation, motor activity and cognitive processes. The aim of the present study was to evaluate the role of D2 receptors in the behavior of rats in the active allothetic place avoidance (AAPA) task. D2 receptor agonist quinpirole and antagonist sulpiride were administered intraperitoneally 20 min prior to behavioral testing. Administration of quinpirole led to dose-dependent increase of locomotion; the spatial efficiency was spared across the dose range studied (0.05-1.0 mg/kg). In contrast, sulpiride decreased locomotor activity at a dose not influencing spatial efficiency (60 mg/kg); the highest dose of sulpiride (100 mg/kg) caused a deficit in both locomotor and spatial behaviors. The results suggest a relatively lesser importance of D2 receptors for spatial efficiency in the AAPA task, with a predominant influence of D2 receptor ligands on motor activity. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.