De novo gastric cancer developing after liver transplantation from deceased donor for biliary atresia: a case report

被引：1

作者：

Higashidate, Naruki ^{[1
]}

Fukahori, Suguru ^{[1
]}

Ishii, Shinji ^{[1
]}

Saikusa, Nobuyuki ^{[1
]}

Hashizume, Naoki ^{[1
]}

Koga, Yoshinori ^{[1
]}

Masui, Daisuke ^{[1
]}

Sakamoto, Saki ^{[1
]}

Tsuruhisa, Shiori ^{[1
]}

Nakahara, Hirotomo ^{[1
]}

Tanaka, Yoshiaki ^{[2
]}

Fukahori, Masaru ^{[3
]}

Miwa, Keisuke ^{[3
]}

Naito, Yoshiki ^{[4
]}

Yagi, Minoru ^{[1
]}

机构：

[1] Kurume Univ, Dept Pediat Surg, Sch Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ Hosp, Div Med Safety Management, Kurume, Fukuoka, Japan

[3] Kurume Univ Hosp, Multidisciplinary Canc Treatment Ctr, Kurume, Fukuoka, Japan

[4] Kurume Univ Hosp, Dept Diagnost Pathol, Kurume, Fukuoka, Japan

来源：

SURGICAL CASE REPORTS | 2021年 / 7卷 / 01期

关键词：

Biliary atresia; Liver transplantation; De novo malignancy; Gastric cancer; SOLID-ORGAN TRANSPLANTATION; MALIGNANCIES; RISK; IMMUNOSUPPRESSION;

D O I：

10.1186/s40792-021-01210-x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background Apart from Kasai's procedure, liver transplantation (LTx) has dramatically improved the outcome of children with biliary atresia (BA). However, de novo malignancy has been reported to be one of the major causes of late mortality after LTx among adults. We report a rare case of de novo gastric cancer developing after LTx for BA received during childhood. Case presentation A 21-year-old male patient who had undergone LTx for BA at age 2 years occasionally visited our outpatient clinic due to symptoms of epigastric pain and dysphagia. Endoscopic examination and computed tomography revealed advanced gastric cancer at the gastroesophageal junction with multiple liver metastases. Despite systemic chemotherapy, the disease progressed, resulting in patient's death 2 years after the diagnosis. Conclusions De novo malignancy in the absence of post-transplant lymphoproliferative disease is rare in pediatric patients who received LTx. To the best of our knowledge, no report has been available on the development of gastric cancer after LTx for BA during childhood. Primary physicians should therefore establish a follow-up plan for patients receiving LTx for BA considering the potential for the development of de novo malignancy, including gastric cancer, despite its rarity.

引用

页数：5