JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling

被引：14
作者：
Ren, Yanlin [1 ,2 ,5 ]
Chen, Dongyin [3 ]
Zhai, Zurong [1 ,2 ]
Chen, Junjie [1 ,2 ]
Li, Aiping [1 ,2 ]
Liang, Yan [2 ,4 ]
Zhou, Jianwei [1 ,2 ]
机构：
[1] Nanjing Med Univ, Sch Publ Hlth, Ctr Global Hlth, Dept Mol Cell Biol & Toxicol, Nanjing 211166, Peoples R China
[2] Nanjing Med Univ, Collaborat Innovat Ctr Canc Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatm, Nanjing 211166, Peoples R China
[3] Nanjing Med Univ, Sch Pharm, Dept Med Chem, Nanjing 211166, Peoples R China
[4] Nanjing Med Univ, Dept Oncol, Affiliated Hosp 1, Nanjing 211166, Peoples R China
[5] Nantong Ctr Dis Control & Prevent, Nantong 226007, Peoples R China
来源：
CELL DEATH DISCOVERY | 2021年 / 7卷 / 01期
基金：
中国国家自然科学基金;
关键词：
CELL-PROLIFERATION; GASTRIC-CANCER; LUNG-CANCER; JWA; EXPRESSION; GROWTH; RESISTANCE; MIGRATION; INVASION; HER2;
D O I：
10.1038/s41420-021-00426-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The overexpression of HER2 is associated with a malignant proliferation of breast cancer. In this study, we developed a non-cytotoxic JWA gene activating compound 1 (JAC1) to inhibit the proliferation of HER2-positive breast cancer cells in vitro and in vivo experimental models. JAC1 increased the ubiquitination of HER2 at the K716 site through the E3 ubiquitin ligase SMURF1 which was due to the decreased expression of NEDD4, the E3 ubiquitin ligase of SMURF1. In conclusion, JAC1 suppresses the proliferation of HER2-positive breast cancer cells through the JWA triggered HER2 ubiquitination signaling. JAC1 may serve as a potential therapeutic agent for HER2-positive breast cancer.
引用
收藏
页数：13
相关论文
共 50 条
  • [41] FGFR1 and HER1 or HER2 co-amplification in breast cancer indicate poor prognosis
    Chen, Shinan
    Qiu, Yan
    Guo, Peng
    Pu, Tianjie
    Feng, Ye
    Bu, Hong
    ONCOLOGY LETTERS, 2018, 15 (06) : 8206 - 8214
  • [42] Epinephrine increases malignancy of breast cancer through p38 MAPK signaling pathway in depressive disorders
    Ouyang, Xueyan
    Zhu, Zhen
    Yang, Chao
    Wang, Li
    Ding, Gang
    Jiang, Feng
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2019, 12 (06): : 1932 - 1946
  • [43] Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model
    Shimizu, Yoshiko
    Furuya, Hideki
    Tamashiro, Paulette M.
    Iino, Kayoko
    Chan, Owen T. M.
    Goodison, Steve
    Pagano, Ian
    Hokutan, Kanani
    Peres, Rafael
    Loo, Lenora W. M.
    Hernandez, Brenda
    Naing, Aung
    Chong, Clayton D. K.
    Rosser, Charles J.
    Kawamori, Toshihiko
    CARCINOGENESIS, 2018, 39 (01) : 47 - 55
  • [44] TGF-β1 contributes to CD8+ Treg induction through p38 MAPK signaling in ovarian cancer microenvironment
    Wu, Meng
    Chen, Xian
    Lou, Jianfang
    Zhang, Shuping
    Zhang, Xiaojie
    Huang, Lei
    Sun, Ruihong
    Huang, Peijun
    Wang, Fang
    Pan, Shiyang
    ONCOTARGET, 2016, 7 (28) : 44534 - 44544
  • [45] Novel flexible heteroarotinoid, SL-1-39, inhibits HER2-positive breast cancer cell proliferation by promoting lysosomal degradation of HER2
    Zou, Hongye
    Sevigny, Mary B.
    Liu, Shengquan
    Madden, David T.
    Louie, Maggie C.
    CANCER LETTERS, 2019, 443 : 157 - 166
  • [46] Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways
    Liu, Yao
    Chen, Li
    Liu, Wenjun
    Li, Dan
    Zeng, Jiuseng
    Tang, Qiong
    Zhang, Yuexin
    Luan, Fei
    Zeng, Nan
    FRONTIERS IN MICROBIOLOGY, 2021, 12
  • [47] Downregulation of MiR-196b-5p impedes cell proliferation and metastasis in breast cancer through regulating COL1A1
    Zhu, Xiaoliang
    Rao, Xuefeng
    Yao, Wu
    Zou, Xia
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 10 (10): : 3122 - 3132
  • [48] Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins
    Merlin, Jean-Louis
    Harle, Alexandre
    Lion, Maeva
    Ramacci, Carole
    Leroux, Agnes
    ONCOLOGY REPORTS, 2013, 30 (04) : 1943 - 1948
  • [49] MicroRNA-194-5p on Proliferation and Invasion of Laryngeal Cancer Cells by Regulating the Expression of SMURF1 and Activating the mTOR Signalling Pathway
    Liu, L.
    Wang, Weiyi
    Xiao, Xuping
    Liu, X.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2022, 84 : 284 - 289
  • [50] Pinocembrin suppresses TGF-β1-induced epithelial-mesenchymal transition and metastasis of human Y-79 retinoblastoma cells through inactivating αvβ3 integrin/FAK/p38α signaling pathway
    Chen, Kun-Shiang
    Shi, Ming-Der
    Chien, Chi-Sheng
    Shih, Yuan-Wei
    CELL AND BIOSCIENCE, 2014, 4
12345